Laccase-catalyzed derivatization of antibiotics with sulfonamide or sulfone structures
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Date
2021
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Basel : MDPI
Abstract
Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of antibiotics with sulfonamide or sulfone structures with 2,5-dihydroxybenzene derivatives to form new heterodimers and heterotrimers. These heteromolecular hybrid products are formed by nuclear amination of the p-hydroquinones with the primary amino group of the sulfonamide or sulfone antibiotics, and they inhibited in vitro the growth of Staphylococcus species, including multidrug-resistant strains.
Description
Keywords
Antibacterial activity, Antimicrobial resistance (AMR), Biotransformation, Laccase, Methicillin-resistant Staphylococcus aureus (MRSA), Multidrug resistance (MDR), Sulfonamide antibiotics, β-lactam antibiotics
Citation
Citation
Mikolasch, A., & Hahn, V. (2021). Laccase-catalyzed derivatization of antibiotics with sulfonamide or sulfone structures (Version publishedVersion, Vol. 9). Version publishedVersion, Vol. 9. Basel : MDPI. https://doi.org//10.3390/microorganisms9112199