Laccase-catalyzed derivatization of antibiotics with sulfonamide or sulfone structures

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Date
2021
Volume
9
Issue
11
Journal
Series Titel
Book Title
Publisher
Basel : MDPI
Abstract

Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of antibiotics with sulfonamide or sulfone structures with 2,5-dihydroxybenzene derivatives to form new heterodimers and heterotrimers. These heteromolecular hybrid products are formed by nuclear amination of the p-hydroquinones with the primary amino group of the sulfonamide or sulfone antibiotics, and they inhibited in vitro the growth of Staphylococcus species, including multidrug-resistant strains.

Description
Keywords
Antibacterial activity, Antimicrobial resistance (AMR), Biotransformation, Laccase, Methicillin-resistant Staphylococcus aureus (MRSA), Multidrug resistance (MDR), Sulfonamide antibiotics, β-lactam antibiotics
Citation
Mikolasch, A., & Hahn, V. (2021). Laccase-catalyzed derivatization of antibiotics with sulfonamide or sulfone structures. 9(11). https://doi.org//10.3390/microorganisms9112199
License
CC BY 4.0 Unported