Laccase-catalyzed derivatization of antibiotics with sulfonamide or sulfone structures

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Date
2021
Volume
9
Issue
11
Journal
Microorganisms
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Publisher
Basel : MDPI
Abstract

Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of antibiotics with sulfonamide or sulfone structures with 2,5-dihydroxybenzene derivatives to form new heterodimers and heterotrimers. These heteromolecular hybrid products are formed by nuclear amination of the p-hydroquinones with the primary amino group of the sulfonamide or sulfone antibiotics, and they inhibited in vitro the growth of Staphylococcus species, including multidrug-resistant strains.

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CC BY 4.0 Unported