Efficient palladium-catalyzed synthesis of 2-aryl propionic acids
dc.bibliographicCitation.firstPage | 3421 | eng |
dc.bibliographicCitation.issue | 15 | eng |
dc.bibliographicCitation.volume | 25 | eng |
dc.contributor.author | Neumann, Helfried | |
dc.contributor.author | Sergeev, Alexey G. | |
dc.contributor.author | Spannenberg, Anke | |
dc.contributor.author | Beller, Matthias | |
dc.date.accessioned | 2021-11-25T07:47:30Z | |
dc.date.available | 2021-11-25T07:47:30Z | |
dc.date.issued | 2020 | |
dc.description.abstract | A flexible two-step, one-pot procedure was developed to synthesize 2-aryl propionic acids including the anti-inflammatory drugs naproxen and flurbiprofen. Optimal results were obtained in the presence of the novel ligand neoisopinocampheyldiphenylphosphine (NISPCPP) (9) which enabled the efficient sequential palladium-catalyzed Heck coupling of aryl bromides with ethylene and hydroxycarbonylation of the resulting styrenes to 2-aryl propionic acids. This cascade transformation leads with high regioselectivity to the desired products in good yields and avoids the need for additional purification steps. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. | eng |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/7472 | |
dc.identifier.uri | https://doi.org/10.34657/6519 | |
dc.language.iso | eng | eng |
dc.publisher | Basel : MDPI | eng |
dc.relation.doi | https://doi.org/10.3390/molecules25153421 | |
dc.relation.essn | 1420-3049 | |
dc.relation.ispartofseries | Molecules : a journal of synthetic chemistry and natural product chemistry 25 (2020), Nr. 15 | eng |
dc.rights.license | CC BY 4.0 Unported | eng |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | eng |
dc.subject | Heck reaction | eng |
dc.subject | Methoxycarbonylation | eng |
dc.subject | Palladium | eng |
dc.subject | Profene | eng |
dc.subject | Styrene | eng |
dc.subject.ddc | 540 | eng |
dc.title | Efficient palladium-catalyzed synthesis of 2-aryl propionic acids | eng |
dc.type | article | eng |
dc.type | Text | eng |
dcterms.bibliographicCitation.journalTitle | Molecules : a journal of synthetic chemistry and natural product chemistry | eng |
tib.accessRights | openAccess | eng |
wgl.contributor | LIKAT | eng |
wgl.subject | Chemie | eng |
wgl.type | Zeitschriftenartikel | eng |
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