Novel monomers in radical ring-opening polymerisation for biodegradable and pH responsive nanoparticles
Date
2019
Volume
10
Issue
39
Journal
Series Titel
Book Title
Publisher
Brookfield, Conn. : Society of Plastic Engineers
Link to publishers version
Abstract
Responsive and biodegradable nanoparticles are essential for functional drug delivery systems. We herein report the first pH sensitive polyester from radical ring-opening polymerisation of novel amine-bearing cyclic ketene acetals (CKAs). The CKAs were synthesised via an intermediate carbonate and the resulting polyesters showed a pKa around pH 6. Together with an initial application in biodegradable nanoparticles, they open the pathway for a new generation of functional polyesters.
Description
Keywords
Biodegradable polymers, Nanoparticles, Polyesters, Polymerization, Biodegradable nanoparticle, Cyclic ketene acetals, Drug delivery system, pH sensitive, PH-responsive, Synthesised, Drug delivery
Citation
Folini, J., Huang, C.-H., Anderson, J. C., Meier, W. P., & Gaitzsch, J. (2019). Novel monomers in radical ring-opening polymerisation for biodegradable and pH responsive nanoparticles. 10(39). https://doi.org//10.1039/c9py01103j
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License
CC BY-NC 3.0 Unported