On an extended interpretation of linkage disequilibrium in genetic case-control association studies
dc.bibliographicCitation.seriesTitle | WIAS Preprints | eng |
dc.bibliographicCitation.volume | 2029 | |
dc.contributor.author | Dickhaus, Thorsten | |
dc.contributor.author | Stange, Jens | |
dc.contributor.author | Demirhan, Haydar | |
dc.date.accessioned | 2016-03-24T17:37:04Z | |
dc.date.available | 2019-06-28T08:13:15Z | |
dc.date.issued | 2014 | |
dc.description.abstract | We are concerned with statistical inference for 2 x 2 x K contingency tables in the context of genetic case-control association studies. Multivariate methods based on asymptotic Gaussianity of vectors of test statistics require information about the asymptotic correlation structure among these test statistics under the global null hypothesis. We show that for a wide variety of test statistics this asymptotic correlation structure is given by the linkage disequilibrium matrix of the K loci under investigation. Three popular choices of test statistics are discussed for illustration. | eng |
dc.description.version | publishedVersion | eng |
dc.format | application/pdf | |
dc.identifier.issn | 2198-5855 | |
dc.identifier.uri | https://doi.org/10.34657/2812 | |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/2917 | |
dc.language.iso | eng | eng |
dc.publisher | Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik | eng |
dc.relation.issn | 0946-8633 | eng |
dc.rights.license | This document may be downloaded, read, stored and printed for your own use within the limits of § 53 UrhG but it may not be distributed via the internet or passed on to external parties. | eng |
dc.rights.license | Dieses Dokument darf im Rahmen von § 53 UrhG zum eigenen Gebrauch kostenfrei heruntergeladen, gelesen, gespeichert und ausgedruckt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. | ger |
dc.subject.ddc | 510 | eng |
dc.subject.other | Asymptotic Gaussianity | eng |
dc.subject.other | chi-squared statistic | eng |
dc.subject.other | contingency table | eng |
dc.subject.other | correlation structure | eng |
dc.subject.other | Delta method | eng |
dc.subject.other | Fisher's exact test | eng |
dc.subject.other | odds ratio | eng |
dc.title | On an extended interpretation of linkage disequilibrium in genetic case-control association studies | eng |
dc.type | Report | eng |
dc.type | Text | eng |
tib.accessRights | openAccess | eng |
wgl.contributor | WIAS | eng |
wgl.subject | Mathematik | eng |
wgl.type | Report / Forschungsbericht / Arbeitspapier | eng |
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