It Takes Three to Tango - the length of the oligothiophene determines the nature of the long-lived excited state and the resulting photocytotoxicity of a Ru(II) photodrug
dc.bibliographicCitation.firstPage | 421 | eng |
dc.bibliographicCitation.issue | 5 | eng |
dc.bibliographicCitation.journalTitle | ChemPhotoChem | eng |
dc.bibliographicCitation.lastPage | 425 | eng |
dc.bibliographicCitation.volume | 5 | eng |
dc.contributor.author | Chettri, Avinash | |
dc.contributor.author | Roque, John A. | |
dc.contributor.author | Schneider, Kilian R.A. | |
dc.contributor.author | Cole, Houston D. | |
dc.contributor.author | Cameron, Colin G. | |
dc.contributor.author | McFarland, Sherri A. | |
dc.contributor.author | Dietzek, Benjamin | |
dc.date.accessioned | 2022-01-14T06:38:39Z | |
dc.date.available | 2022-01-14T06:38:39Z | |
dc.date.issued | 2021 | |
dc.description.abstract | TLD1433 is the first Ru(II) complex to be tested as a photodynamic therapy agent in a clinical trial. In this contribution we study TLD1433 in the context of structurally-related Ru(II)-imidozo[4,5-f][1,10]phenanthroline (ip) complexes appended with thiophene rings to decipher the unique photophysical properties which are associated with increasing oligothiophene chain length. Substitution of the ip ligand with ter- or quaterthiophene changes the nature of the long-lived triplet state from metal-to-ligand charge-transfer to 3ππ* character. The addition of the third thiophene thus presents a critical juncture which not only determines the photophysics of the complex but most importantly its capacity for 1O2 generation and hence the potential of the complex to be used as a photocytotoxic agent. | eng |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/7808 | |
dc.identifier.uri | https://doi.org/10.34657/6849 | |
dc.language.iso | eng | eng |
dc.publisher | Weinheim : Wiley-VCH | eng |
dc.relation.doi | https://doi.org/10.1002/cptc.202000283 | |
dc.relation.essn | 2367-0932 | |
dc.rights.license | CC BY-NC-ND 4.0 Unported | eng |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | eng |
dc.subject.ddc | 540 | eng |
dc.subject.other | excited states | eng |
dc.subject.other | photodynamic therapy | eng |
dc.subject.other | ruthenium | eng |
dc.subject.other | singlet oxygen | eng |
dc.subject.other | TLD1433 | eng |
dc.subject.other | triplet states | eng |
dc.title | It Takes Three to Tango - the length of the oligothiophene determines the nature of the long-lived excited state and the resulting photocytotoxicity of a Ru(II) photodrug | eng |
dc.type | Article | eng |
dc.type | Text | eng |
tib.accessRights | openAccess | eng |
wgl.contributor | IPHT | eng |
wgl.subject | Chemie | eng |
wgl.type | Zeitschriftenartikel | eng |
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