The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes. © 2019 The Author(s).

URI

https://doi.org/10.34657/116
https://oa.tib.eu/renate/handle/123456789/4845

Citation

Formicola, B., Dal, M. R., Montefusco-Pereira, C. V., Lehr, C.-M., Koch, M., Russo, L., et al. (2019). The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB (London : BioMed Central). London : BioMed Central. https://doi.org//10.1186/s12951-019-0546-3

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Ingenieurwissenschaften

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CC BY 4.0 Unported

https://creativecommons.org/licenses/by/4.0/

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