Multiscale modeling of palisade formation in gliobastoma multiforme
dc.bibliographicCitation.volume | 2012 | |
dc.contributor.author | Caiazzo, Alfonso | |
dc.contributor.author | Ramis-Conde, Ignacio | |
dc.date.accessioned | 2016-03-24T17:37:02Z | |
dc.date.available | 2019-06-28T08:12:50Z | |
dc.date.issued | 2014 | |
dc.description.abstract | Palisades are characteristic tissue aberrations that arise in glioblastomas. Observation of palisades is considered as a clinical indicator of the transition from a noninvasive to an invasive tumour. In this article we propose a computational model to study the influence of genotypic and phenotypic heterogeneity in palisade formation. For this we produced three dimensional realistic simulations, based on a multiscale hybrid model, coupling the evolution of tumour cells and the oxygen diffusion in tissue, that depict the shape of palisades during its formation. Our results can be summarized as the following: (1) we show that cell heterogeneity is a crucial factor in palisade formation and tumour growth; (2) we present results that can explain the observed fact that recursive tumours are more malignant than primary tumours; and (3) the presented simulations can provide to clinicians and biologists for a better understanding of palisades 3D structure as well as glioblastomas growth dynamics. | eng |
dc.description.version | publishedVersion | eng |
dc.format | application/pdf | |
dc.identifier.issn | 0946-8633 | |
dc.identifier.uri | https://doi.org/10.34657/2706 | |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/2893 | |
dc.language.iso | eng | eng |
dc.publisher | Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik | eng |
dc.relation.ispartofseries | Preprint / Weierstraß-Institut für Angewandte Analysis und Stochastik , Volume 2012, ISSN 0946 – 8633 | eng |
dc.rights.license | This document may be downloaded, read, stored and printed for your own use within the limits of § 53 UrhG but it may not be distributed via the internet or passed on to external parties. | eng |
dc.rights.license | Dieses Dokument darf im Rahmen von § 53 UrhG zum eigenen Gebrauch kostenfrei heruntergeladen, gelesen, gespeichert und ausgedruckt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. | ger |
dc.subject | Palisades | eng |
dc.subject | glioblastoma | eng |
dc.subject | multiscale hybrid modeling | eng |
dc.subject | force-based | eng |
dc.subject | finite elements | eng |
dc.subject.ddc | 510 | eng |
dc.title | Multiscale modeling of palisade formation in gliobastoma multiforme | eng |
dc.type | report | eng |
dc.type | Text | eng |
dcterms.bibliographicCitation.journalTitle | Preprint / Weierstraß-Institut für Angewandte Analysis und Stochastik | eng |
tib.accessRights | openAccess | eng |
wgl.contributor | WIAS | eng |
wgl.subject | Mathematik | eng |
wgl.type | Report / Forschungsbericht / Arbeitspapier | eng |
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