Chemokine‐Capturing Wound Contact Layer Rescues Dermal Healing
dc.bibliographicCitation.firstPage | 2100293 | |
dc.bibliographicCitation.issue | 18 | |
dc.bibliographicCitation.journalTitle | Advanced Science | eng |
dc.bibliographicCitation.volume | 8 | |
dc.contributor.author | Schirmer, Lucas | |
dc.contributor.author | Atallah, Passant | |
dc.contributor.author | Freudenberg, Uwe | |
dc.contributor.author | Werner, Carsten | |
dc.date.accessioned | 2023-01-24T10:35:09Z | |
dc.date.available | 2023-01-24T10:35:09Z | |
dc.date.issued | 2021 | |
dc.description.abstract | Excessive inflammation often impedes the healing of chronic wounds. Scavenging of chemokines by multiarmed poly(ethylene glycol)-glycosaminoglycan (starPEG-GAG) hydrogels has recently been shown to support regeneration in a diabetic mouse chronic skin wound model. Herein, a textile-starPEG-GAG composite wound contact layer (WCL) capable of selectively sequestering pro-inflammatory chemokines is reported. Systematic variation of the local and integral charge densities of the starPEG-GAG hydrogel component allows for tailoring its affinity profile for biomolecular signals of the wound milieu. The composite WCL is subsequently tested in a large animal (porcine) model of human wound healing disorders. Dampening excessive inflammatory signals without affecting the levels of pro-regenerative growth factors, the starPEG-GAG hydrogel-based WCL treatment induced healing with increased granulation tissue formation, angiogenesis, and deposition of connective tissue (collagen fibers). Thus, this biomaterials technology expands the scope of a new anti-inflammatory therapy toward clinical use. | eng |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/10998 | |
dc.identifier.uri | http://dx.doi.org/10.34657/10024 | |
dc.language.iso | eng | |
dc.publisher | Weinheim : Wiley-VCH | |
dc.relation.doi | https://doi.org/10.1002/advs.202100293 | |
dc.relation.essn | 2198-3844 | |
dc.rights.license | CC BY 4.0 Unported | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject.ddc | 500 | |
dc.subject.ddc | 600 | |
dc.subject.ddc | 624 | |
dc.subject.other | chronic wounds | eng |
dc.subject.other | glycosaminoglycans | eng |
dc.subject.other | hydrogels | eng |
dc.subject.other | wound healing | eng |
dc.title | Chemokine‐Capturing Wound Contact Layer Rescues Dermal Healing | eng |
dc.type | Article | eng |
dc.type | Text | eng |
tib.accessRights | openAccess | |
wgl.contributor | IPF | |
wgl.subject | Ingenieurwissenschaften | ger |
wgl.subject | Medizin, Gesundheit | ger |
wgl.type | Zeitschriftenartikel | ger |
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