C-F bond activation under transition-metal-free conditions
dc.bibliographicCitation.firstPage | 1630 | eng |
dc.bibliographicCitation.issue | 10 | eng |
dc.bibliographicCitation.journalTitle | Science China = Scientia Sinica : Chemistry | eng |
dc.bibliographicCitation.lastPage | 1659 | eng |
dc.bibliographicCitation.volume | 64 | eng |
dc.contributor.author | Ai, Han-Jun | |
dc.contributor.author | Ma, Xingxing | |
dc.contributor.author | Song, Qiuling | |
dc.contributor.author | Wu, Xiao-Feng | |
dc.date.accessioned | 2022-04-14T08:51:13Z | |
dc.date.available | 2022-04-14T08:51:13Z | |
dc.date.issued | 2021 | |
dc.description.abstract | The unique properties of fluorine-containing organic compounds make fluorine substitution attractive for the development of pharmaceuticals and various specialty materials, which have inspired the evolution of diverse C-F bond activation techniques. Although many advances have been made in functionalizations of activated C-F bonds utilizing transition metal complexes, there are fewer approaches available for nonactivated C-F bonds due to the difficulty in oxidative addition of transition metals to the inert C-F bonds. In this regard, using Lewis acid to abstract the fluoride and light/radical initiator to generate the radical intermediate have emerged as powerful tools for activating those inert C-F bonds. Meanwhile, these transition-metal-free processes are greener, economical, and for the pharmaceutical industry, without heavy metal residues. This review provides an overview of recent C-F bond activations and functionalizations under transition-metal-free conditions. The key mechanisms involved are demonstrated and discussed in detail. Finally, a brief discussion on the existing limitations of this field and our perspective are presented. | eng |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/8697 | |
dc.identifier.uri | https://doi.org/10.34657/7735 | |
dc.language.iso | eng | eng |
dc.publisher | Beijing : Science China Press | eng |
dc.relation.doi | https://doi.org/10.1007/s11426-021-1040-2 | |
dc.relation.essn | 1869-1870 | |
dc.rights.license | CC BY 4.0 Unported | eng |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | eng |
dc.subject.ddc | 540 | eng |
dc.subject.other | C-F activation | eng |
dc.subject.other | coupling | eng |
dc.subject.other | fluorinated compounds | eng |
dc.subject.other | transition-metal-free | eng |
dc.title | C-F bond activation under transition-metal-free conditions | eng |
dc.type | Article | eng |
dc.type | Text | eng |
tib.accessRights | openAccess | eng |
wgl.contributor | LIKAT | eng |
wgl.subject | Chemie | eng |
wgl.type | Zeitschriftenartikel | eng |
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