CC BY 3.0 UnportedMicheel, MathiasTorres Ziegenbein, ChristianGilch, PeterRyseck, Gerald2022-08-172022-08-172015https://oa.tib.eu/renate/handle/123456789/10057https://doi.org/10.34657/9095(6-4) Photolesions between adjacent pyrimidine DNA bases are prone to secondary photochemistry. It has been shown that singlet excited (6-4) moieties form Dewar valence isomers as well as triplet excitations. We here report on the triplet state of a minimal model for the (6-4) photolesion, 1-methyl-2(1H)-pyrimidinone. Emphasis is laid on its ability to abstract hydrogen atoms from alcohols and carbohydrates. Steady-state and time-resolved experiments consistently yield bimolecular rate constants of ∼104 M−1 s−1 for the hydrogen abstraction. The process also occurs intramolecularly as experiments on zebularine (1-(β-D-ribofuranosyl)-2(1H)-pyrimidinone) show.enghttps://creativecommons.org/licenses/by/3.0/620cytidineDNAhydrogenmethanolpyrimidin-2-one beta-ribofuranosideArticle