CC BY 4.0 UnportedNeumann, HelfriedSergeev, Alexey G.Spannenberg, AnkeBeller, Matthias2021-11-252021-11-252020https://oa.tib.eu/renate/handle/123456789/7472https://doi.org/10.34657/6519A flexible two-step, one-pot procedure was developed to synthesize 2-aryl propionic acids including the anti-inflammatory drugs naproxen and flurbiprofen. Optimal results were obtained in the presence of the novel ligand neoisopinocampheyldiphenylphosphine (NISPCPP) (9) which enabled the efficient sequential palladium-catalyzed Heck coupling of aryl bromides with ethylene and hydroxycarbonylation of the resulting styrenes to 2-aryl propionic acids. This cascade transformation leads with high regioselectivity to the desired products in good yields and avoids the need for additional purification steps. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.enghttps://creativecommons.org/licenses/by/4.0/540Heck reactionMethoxycarbonylationPalladiumProfeneStyreneArticle