CC BY-NC 3.0 UnportedFolini, JennyHuang, Chao-HungAnderson, James C.Meier, Wolfgang P.Gaitzsch, Jens2021-12-132021-12-132019https://oa.tib.eu/renate/handle/123456789/7694https://doi.org/10.34657/6741Responsive and biodegradable nanoparticles are essential for functional drug delivery systems. We herein report the first pH sensitive polyester from radical ring-opening polymerisation of novel amine-bearing cyclic ketene acetals (CKAs). The CKAs were synthesised via an intermediate carbonate and the resulting polyesters showed a pKa around pH 6. Together with an initial application in biodegradable nanoparticles, they open the pathway for a new generation of functional polyesters.enghttps://creativecommons.org/licenses/by-nc/3.0/540Biodegradable polymersNanoparticlesPolyestersPolymerizationBiodegradable nanoparticleCyclic ketene acetalsDrug delivery systempH sensitivePH-responsiveSynthesisedDrug deliveryArticle