CC BY 4.0 UnportedSchulze, AgnesBreite, DanielKim, YongkyumSchmidt, MartinThomas, IsabellWent, MarcoFischer, KristinaPrager, Andrea2023-01-202023-01-202017-3-9https://oa.tib.eu/renate/handle/123456789/10957http://dx.doi.org/10.34657/9983To generate polyethersulfone membranes with a biocatalytically active surface, pancreatin was covalently immobilized. Pancreatin is a mixture of digestive enzymes such as protease, lipase, and amylase. The resulting membranes exhibit self-cleaning properties after “switching on” the respective enzyme by adjusting pH and temperature. Thus, the membrane surface can actively degrade a fouling layer on its surface and regain initial permeability. Fouling tests with solutions of protein, oil, and mixtures of both, were performed, and the membrane’s ability to self-clean the fouled surface was characterized. Membrane characterization was conducted by investigation of the immobilized enzyme concentration, enzyme activity, water permeation flux, fouling tests, porosimetry, X-ray photoelectron spectroscopy, and scanning electron microscopy.enghttps://creativecommons.org/licenses/by/4.0/540Catalytic propertiesEnzyme immobilizationPolymer membraneSelf-cleaningSurface modificationArticle