ACS AuthorChoiceMartinez-Cisneros, C.S.Sanchez, S.Xi, W.Schmidt, O.G.2020-11-122020-11-122014https://doi.org/10.34657/4524https://oa.tib.eu/renate/handle/123456789/5895We present ultracompact three-dimensional tubular structures integrating Au-based electrodes as impedimetric microsensors for the in-flow determination of mono- and divalent ionic species and HeLa cells. The microsensors show an improved performance of 2 orders of magnitude (limit of detection = 0.1 nM for KCl) compared to conventional planar conductivity detection systems integrated in microfluidic platforms and the capability to detect single HeLa cells in flowing phosphate buffered saline. These highly integrated conductivity tubular sensors thus open new possibilities for lab-in-a-tube devices for bioapplications such as biosensing and bioelectronics.enghttps://pubs.acs.org/page/policy/authorchoice_termsofuse.html6203D-microsensorlab-in-a-tubenanomembranesRolled-up electronicsThree dimensionalTubes (components)Biosensing applicationsConductivity detectionlab-in-a-tubeLimit of detectionMicrofluidic platformsNanomembranesOrders of magnitudePhosphate-buffered salinesMicrosensorsgoldionchemistrydeviceselectrochemical analysiselectrodeequipment designgenetic proceduresHeLa cell linehumanimpedancemicrofluidic analysissingle cell analysisBiosensing TechniquesElectric ImpedanceElectrochemical TechniquesElectrodesEquipment DesignGoldHeLa CellsHumansIonsMicrofluidic Analytical TechniquesSingle-Cell AnalysisArticle