CC BY 3.0 UnportedAvitabile, D.Salchert, K.Werner, C.Capogrossi, M.C.Pesce, M.2020-09-112020-09-112013https://doi.org/10.34657/4252https://oa.tib.eu/renate/handle/123456789/5623Various reports have indicated low survival of injected progenitors into unfavorable environments such as the ischemic myocardium or lower limb tissues. This represents a major bottleneck in stem-cell-based cardiovascular regenerative medicine. Strategies to enhance survival of these cells in recipient tissues have been therefore sought to improve stem cell survival and ensure long-term engraftment. In the present contribution, we show that embedding human cord blood-derived CD34+ cells into a collagen I-based hydrogel containing cytokines is a suitable strategy to promote stem cell proliferation and protect these cells from anoxia-induced apoptosis.enghttps://creativecommons.org/licenses/by/3.0/370CD34 antigencollagen type 1cytokineoxygenapoptosisarticlecell hypoxiacell proliferationcell protectioncell survivalcontrolled studyembeddingendothelial progenitor cellhumanhuman cellhuman cell culturehydrogelumbilical cord bloodcell proliferationchemistrycytologyfetus bloodflow cytometrymetabolismstem cellstem cell transplantationAntigens, CD34ApoptosisCell HypoxiaCell ProliferationCell SurvivalCollagen Type IFetal BloodFlow CytometryHumansHydrogelsOxygenStem Cell TransplantationStem CellsArticle