CC BY 4.0 UnportedFormicola, BeatriceDal, Magro, RobertaMontefusco-Pereira, Carlos V.Lehr, Claus‑MichaelKoch, MarcusRusso, LauraGrasso, GianvitoDeriu, Marco A.Danani, AndreaBourdoulous, SandrineRe, Francesca2020-01-142020-01-142019https://doi.org/10.34657/116https://oa.tib.eu/renate/handle/123456789/4845We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes. © 2019 The Author(s).enghttps://creativecommons.org/licenses/by/4.0/570610Blood-brain barrierBrainChlorotoxinDoxorubicinDrug deliveryGlioblastomaLiposomesNanoparticlesArticle