CC BY 4.0 UnportedMarquet, MikeHölzer, MartinPletz, Mathias WViehweger, AdrianMakarewicz, OliwiaEhricht, RalfBrandt, Christian2023-02-062023-02-062022https://oa.tib.eu/renate/handle/123456789/11232http://dx.doi.org/10.34657/10268Phages are among the most abundant and diverse biological entities on earth. Phage prediction from sequence data is a crucial first step to understanding their impact on the environment. A variety of bacteriophage prediction tools have been developed over the years. They differ in algorithmic approach, results, and ease of use. We, therefore, developed "What the Phage"(WtP), an easy-to-use and parallel multitool approach for phage prediction combined with an annotation and classification downstream strategy, thus supporting the user's decision-making process by summarizing the results of the different prediction tools in charts and tables. WtP is reproducible and scales to thousands of datasets through a workflow manager (Nextflow). WtP is freely available under a GPL-3.0 license (https://github.com/replikation/What_the_Phage).enghttps://creativecommons.org/licenses/by/4.0570610Dockereasy to usemultitool approachNextflowphage predictionscalableArticle