CC BY 4.0 UnportedMikolasch, AnnettHahn, Veronika2023-05-222023-05-222021https://oa.tib.eu/renate/handle/123456789/12166http://dx.doi.org/10.34657/11199Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of antibiotics with sulfonamide or sulfone structures with 2,5-dihydroxybenzene derivatives to form new heterodimers and heterotrimers. These heteromolecular hybrid products are formed by nuclear amination of the p-hydroquinones with the primary amino group of the sulfonamide or sulfone antibiotics, and they inhibited in vitro the growth of Staphylococcus species, including multidrug-resistant strains.enghttps://creativecommons.org/licenses/by/4.0570Antibacterial activityAntimicrobial resistance (AMR)BiotransformationLaccaseMethicillin-resistant Staphylococcus aureus (MRSA)Multidrug resistance (MDR)Sulfonamide antibioticsβ-lactam antibioticsArticle