CC BY 4.0 UnportedXu, WenjingRudov, AndreyOppermann, AlexWypysek, SarahKather, MichaelSchroeder, RicardaRichtering, WalterPotemkin, Igor I.Wöll, DominikPich, Andrij2021-07-302021-07-302020https://oa.tib.eu/renate/handle/123456789/6446https://doi.org/10.34657/5493Controlling the distribution of ionizable groups of opposite charge in microgels is an extremely challenging task, which could open new pathways to design a new generation of stimuli-responsive colloids. Herein, we report a straightforward approach for the synthesis of polyampholyte Janus-like microgels, where ionizable groups of opposite charge are located on different sides of the colloidal network. This synthesis approach is based on the controlled self-assembly of growing polyelectrolyte microgel precursors during the precipitation polymerization process. We confirmed the morphology of polyampholyte Janus-like microgels and demonstrate that they are capable of responding quickly to changes in both pH and temperature in aqueous solutions. © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.enghttps://creativecommons.org/licenses/by/4.0/540Janus-like microgelsmolecular modelingpolyampholyteresponsive materialsself-assemblyArticle