CC BY-NC 3.0 UnportedSingh P.Deckert-Gaudig T.Zhang Z.Deckert V.2021-09-072021-09-072020https://oa.tib.eu/renate/handle/123456789/6739https://doi.org/10.34657/5786Surface plasmons can provide a novel route to induce and simultaneously monitor selective bond formation and breakage. Here pH-induced protonation, followed by plasmon-induced deprotonation of 2-mercaptopyridine was investigated using surface- and tip-enhanced Raman scattering (SERS and TERS). A large difference in the deprotonation rate between SERS and TERS will be demonstrated and discussed with respect to hot-spot distribution. © 2020 The Royal Society of Chemistry.enghttps://creativecommons.org/licenses/by-nc/3.0/540Surface plasmons2-mercaptopyridineBond formationHot spotNovel routeTip-enhanced Raman scatteringsDeprotonationArticle