CC BY 3.0 UnportedSchirmer, LucasHoornaert, ChloéLe Blon, DebbieEigel, DimitriNeto, CatiaGumbleton, MarkWelzel, Petra B.Rosser, Anne E.Werner, CarstenPonsaerts, PeterNewland, Ben2021-09-142021-09-142020https://oa.tib.eu/renate/handle/123456789/6793https://doi.org/10.34657/5840Interleukin-13 (IL-13) drives cells of myeloid origin towards a more anti-inflammatory phenotype, but delivery to the brain remains problematic. Herein, we show that heparin-based cryogel microcarriers load high amounts of IL-13, releasing it slowly. Intra-striatal injection of loaded microcarriers caused local up-regulation of ARG1 in myeloid cells for pro-regenerative immunomodulation in the brain. © 2020 The Royal Society of Chemistry.enghttps://creativecommons.org/licenses/by/3.0/540Anti-inflammatoriesControlled deliveryCryogelsImmuno modulationsInterleukin-13MicrocarriersMyeloid cellsUp-regulationPolysaccharidescryogelglial fibrillary acidic proteinheparininterleukin 13major histocompatibility antigen class 2adultanimal cellanimal experimentanimal tissueArticlebone marrow cellcontrolled drug releasecontrolled studydrug delivery systemgene expressionimmune responseimmunohistochemistryimmunomodulationin vitro studyin vivo studyintrastriatal drug administrationmacrophage activationmicrogliamousenonhumanpriority journalupregulationArticle