CC BY 4.0 UnportedChae, Soo SangJung, Joo HyunChoi, Won JinPark, Joung KyuBaik, Hong KooJung, JongjinKo, Hyuk Wan2022-10-212022-10-212019https://oa.tib.eu/renate/handle/123456789/10289http://dx.doi.org/10.34657/9325Precise modulation of polymer brush in its thickness and grafting density can cause unexpected cell behaviors and regulated bioactivities. Herein, a nanoscale poly(dimethylsiloxane) (PDMS) brush was employed to use as a controllable material for cell adhesion. Facile fabrication of ultrathin monolayer PDMS nanobrush on an underlying substrate facilitated regaining cell adhesion through long-range cell attractive forces such as the van der Waals forces. We showed that cell adhesion is diminished by increasing the number of nanobrush layers, causing a gradual decrease of the effectiveness of the long-range force. The result demonstrates that ultrathin PDMS nanobrush can either promote or inhibit cell adhesion, which is required for various biomedical fields such as tissue-engineering, anti-fouling coating, and implantable biomaterials and sensors.enghttps://creativecommons.org/licenses/by/4.0/500600baysilonbiomaterialdimeticonenanomaterialoxygenpolymerArticle