Browsing by Author "Kismihók, G."
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- ItemINSPIRE: A European training network to foster research and training in cardiovascular safety pharmacology(Amsterdam : Elsevier B.V., 2020) Guns, P.-J.D.; Guth, B.D.; Braam, S.; Kosmidis, G.; Matsa, E.; Delaunois, A.; Gryshkova, V.; Bernasconi, S.; Knot, H.J.; Shemesh, Y.; Chen, A.; Markert, M.; Fernández, M.A.; Lombardi, D.; Grandmont, C.; Cillero-Pastor, B.; Heeren, R.M.A.; Martinet, W.; Woolard, J.; Skinner, M.; Segers, V.F.M.; Franssen, C.; Van Craenenbroeck, E.M.; Volders, P.G.A.; Pauwelyn, T.; Braeken, D.; Yanez, P.; Correll, K.; Yang, X.; Prior, H.; Kismihók, G.; De Meyer, G.R.Y.; Valentin, J.-P.Safety pharmacology is an essential part of drug development aiming to identify, evaluate and investigate undesirable pharmacodynamic properties of a drug primarily prior to clinical trials. In particular, cardiovascular adverse drug reactions (ADR) have halted many drug development programs. Safety pharmacology has successfully implemented a screening strategy to detect cardiovascular liabilities, but there is room for further refinement. In this setting, we present the INSPIRE project, a European Training Network in safety pharmacology for Early Stage Researchers (ESRs), funded by the European Commission's H2020-MSCA-ITN programme. INSPIRE has recruited 15 ESR fellows that will conduct an individual PhD-research project for a period of 36 months. INSPIRE aims to be complementary to ongoing research initiatives. With this as a goal, an inventory of collaborative research initiatives in safety pharmacology was created and the ESR projects have been designed to be complementary to this roadmap. Overall, INSPIRE aims to improve cardiovascular safety evaluation, either by investigating technological innovations or by adding mechanistic insight in emerging safety concerns, as observed in the field of cardio-oncology. Finally, in addition to its hands-on research pillar, INSPIRE will organize a number of summer schools and workshops that will be open to the wider community as well. In summary, INSPIRE aims to foster both research and training in safety pharmacology and hopes to inspire the future generation of safety scientists.
- ItemSurvey vs Scraped Data: Comparing Time Series Properties of Web and Survey Vacancy Data(Berlin : Springer Nature, 2019) De Pedraza, P.; Visintin, S.; Tijdens, K.; Kismihók, G.This paper studies the relationship between a vacancy population obtained from web crawling and vacancies in the economy inferred by a National Statistics Office (NSO) using a traditional method. We compare the time series properties of samples obtained between 2007 and 2014 by Statistics Netherlands and by a web scraping company. We find that the web and NSO vacancy data present similar time series properties, suggesting that both time series are generated by the same underlying phenomenon: the real number of new vacancies in the economy. We conclude that, in our case study, web-sourced data are able to capture aggregate economic activity in the labor market.