Adhesive and Self-Healing Polyurethanes with Tunable Multifunctionality

dc.bibliographicCitation.firstPage9795682
dc.bibliographicCitation.journalTitleResearch : official journal of CAST : a Science Partner journaleng
dc.bibliographicCitation.volume2022
dc.contributor.authorZhou, Lei
dc.contributor.authorZhang, Lu
dc.contributor.authorLi, Peichuang
dc.contributor.authorMaitz, Manfred F.
dc.contributor.authorWang, Kebing
dc.contributor.authorShang, Tengda
dc.contributor.authorDai, Sheng
dc.contributor.authorFu, Yudie
dc.contributor.authorZhao, Yuancong
dc.contributor.authorYang, Zhilu
dc.contributor.authorWang, Jin
dc.contributor.authorLi, Xin
dc.date.accessioned2023-02-22T06:09:18Z
dc.date.available2023-02-22T06:09:18Z
dc.date.issued2022
dc.description.abstractMany polyurethanes (PUs) are blood-contacting materials due to their good mechanical properties, fatigue resistance, cytocompatibility, biosafety, and relatively good hemocompatibility. Further functionalization of the PUs using chemical synthetic methods is especially attractive for expanding their applications. Herein, a series of catechol functionalized PU (CPU-PTMEG) elastomers containing variable molecular weight of polytetramethylene ether glycol (PTMEG) soft segment are reported by stepwise polymerization and further introduction of catechol. Tailoring the molecular weight of PTMEG fragment enables a regulable catechol content, mobility of the chain segment, hydrogen bond and microphase separation of the C-PU-PTMEG elastomers, thus offering tunability of mechanical strength (such as breaking strength from 1.3 MPa to 5.7 MPa), adhesion, self-healing efficiency (from 14.9% to 96.7% within 2 hours), anticoagulant, antioxidation, anti-inflammatory properties and cellular growth behavior. As cardiovascular stent coatings, the C-PU-PTMEGs demonstrate enough flexibility to withstand deformation during the balloon dilation procedure. Of special importance is that the C-PU-PTMEG-coated surfaces show the ability to rapidly scavenge free radicals to maintain normal growth of endothelial cells, inhibit smooth muscle cell proliferation, mediate inflammatory response, and reduce thrombus formation. With the universality of surface adhesion and tunable multifunctionality, these novel C-PU-PTMEG elastomers should find potential usage in artificial heart valves and surface engineering of stents.eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/11476
dc.identifier.urihttp://dx.doi.org/10.34657/10509
dc.language.isoeng
dc.publisher[Beijing] : China Association for Science and Technology
dc.relation.doihttps://doi.org/10.34133/2022/9795682
dc.relation.essn2639-5274
dc.rights.licenseCC BY 4.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subject.ddc333.7
dc.subject.ddc500
dc.subject.ddc600
dc.subject.otherCytocompatibilityeng
dc.subject.otherFatigue-resistanceeng
dc.subject.otherFunctionalizationseng
dc.subject.otherFunctionalizedeng
dc.subject.otherHaemocompatibilityeng
dc.subject.otherMultifunctionalityeng
dc.subject.otherSelf-healingeng
dc.subject.otherSoft segmentseng
dc.subject.otherSynthetic methodseng
dc.subject.otherTunableseng
dc.titleAdhesive and Self-Healing Polyurethanes with Tunable Multifunctionalityeng
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccess
wgl.contributorIPF
wgl.subjectUmweltwissenschaftenger
wgl.typeZeitschriftenartikelger
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