Exploring the evolution and epidemiology of European CC1-MRSA-IV: tracking a multidrug-resistant community-associated meticillin-resistant Staphylococcus aureus clone
dc.bibliographicCitation.firstPage | 000601 | eng |
dc.bibliographicCitation.issue | 7 | eng |
dc.bibliographicCitation.journalTitle | Microbial genomics | eng |
dc.bibliographicCitation.volume | 7 | eng |
dc.contributor.author | Earls, Megan R. | |
dc.contributor.author | Steinig, Eike J. | |
dc.contributor.author | Monecke, Stefan | |
dc.contributor.author | Samaniego Castruita, José A. | |
dc.contributor.author | Simbeck, Alexandra | |
dc.contributor.author | Schneider-Brachert, Wulf | |
dc.contributor.author | Vremerǎ, Teodora | |
dc.contributor.author | Dorneanu, Olivia S. | |
dc.contributor.author | Loncaric, Igor | |
dc.contributor.author | Bes, Michèle | |
dc.contributor.author | Lacoma, Alicia | |
dc.contributor.author | Prat Aymerich, Cristina | |
dc.contributor.author | Wernery, Ulrich | |
dc.contributor.author | Armengol-Porta, Marc | |
dc.contributor.author | Blomfeldt, Anita | |
dc.contributor.author | Duchene, Sebastian | |
dc.contributor.author | Bartels, Mette D. | |
dc.contributor.author | Ehricht, Ralf | |
dc.contributor.author | Coleman, David C. | |
dc.date.accessioned | 2022-03-29T06:06:17Z | |
dc.date.available | 2022-03-29T06:06:17Z | |
dc.date.issued | 2021 | |
dc.description.abstract | This study investigated the evolution and epidemiology of the community-associated and multidrug-resistant Staphylococcus aureus clone European CC1-MRSA-IV. Whole-genome sequences were obtained for 194 European CC1-MRSA-IV isolates (189 of human and 5 of animal origin) from 12 countries, and 10 meticillin-susceptible precursors (from North-Eastern Romania; all of human origin) of the clone. Phylogenetic analysis was performed using a maximum-likelihood approach, a time-measured phylogeny was reconstructed using Bayesian analysis, and in silico microarray genotyping was performed to identify resistance, virulence-associated and SCCmec (staphylococcal cassette chromosome mec) genes. Isolates were typically sequence type 1 (190/204) and spa type t127 (183/204). Bayesian analysis indicated that European CC1-MRSA-IV emerged in approximately 1995 before undergoing rapid expansion in the late 1990s and 2000s, while spreading throughout Europe and into the Middle East. Phylogenetic analysis revealed an unstructured meticillin-resistant S. aureus (MRSA) population, lacking significant geographical or temporal clusters. The MRSA were genotypically multidrug-resistant, consistently encoded seh, and intermittently (34/194) encoded an undisrupted hlb gene with concomitant absence of the lysogenic phage-encoded genes sak and scn. All MRSA also harboured a characteristic ~5350 nt insertion in SCCmec adjacent to orfX. Detailed demographic data from Denmark showed that there, the clone is typically (25/35) found in the community, and often (10/35) among individuals with links to South-Eastern Europe. This study elucidated the evolution and epidemiology of European CC1-MRSA-IV, which emerged from a meticillin-susceptible lineage prevalent in North-Eastern Romania before disseminating rapidly throughout Europe. | eng |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/8412 | |
dc.identifier.uri | https://doi.org/10.34657/7450 | |
dc.language.iso | eng | eng |
dc.publisher | London : Soc. | eng |
dc.relation.doi | https://doi.org/10.1099/MGEN.0.000601 | |
dc.relation.essn | 2057-5858 | |
dc.rights.license | CC BY-NC 4.0 Unported | eng |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | eng |
dc.subject.ddc | 570 | eng |
dc.subject.ddc | 610 | eng |
dc.subject.other | CA-MRSA | eng |
dc.subject.other | Epidemiology | eng |
dc.subject.other | European CC1-MRSA-IV clone | eng |
dc.subject.other | Evolution | eng |
dc.subject.other | Phylogenomics | eng |
dc.subject.other | Transmission | eng |
dc.title | Exploring the evolution and epidemiology of European CC1-MRSA-IV: tracking a multidrug-resistant community-associated meticillin-resistant Staphylococcus aureus clone | eng |
dc.type | Article | eng |
dc.type | Text | eng |
tib.accessRights | openAccess | eng |
wgl.contributor | IPHT | eng |
wgl.subject | Biowissensschaften/Biologie | eng |
wgl.type | Zeitschriftenartikel | eng |
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