Size control in mammalian cells involves modulation of both growth rate and cell cycle duration
dc.contributor.author | Cadar, Clotilde | |
dc.contributor.author | Monnier, Sylvain | |
dc.contributor.author | Grilli, Jacopo | |
dc.contributor.author | Sáez, Pablo J. | |
dc.contributor.author | Srivastava, Nishit | |
dc.contributor.author | Attia, Rafaele | |
dc.contributor.author | Terriac, Emmanuel | |
dc.contributor.author | Baum, Buzz | |
dc.contributor.author | Cosentino-Lagomarsino, Marco | |
dc.contributor.author | Piel, Matthieu | |
dc.date.accessioned | 2018-11-27T13:55:23Z | |
dc.date.available | 2019-06-28T13:58:32Z | |
dc.date.issued | 2018 | |
dc.description.abstract | Despite decades of research, how mammalian cell size is controlled remains unclear because of the difficulty of directly measuring growth at the single-cell level. Here we report direct measurements of single-cell volumes over entire cell cycles on various mammalian cell lines and primary human cells. We find that, in a majority of cell types, the volume added across the cell cycle shows little or no correlation to cell birth size, a homeostatic behavior called “adder”. This behavior involves modulation of G1 or S-G2 duration and modulation of growth rate. The precise combination of these mechanisms depends on the cell type and the growth condition. We have developed a mathematical framework to compare size homeostasis in datasets ranging from bacteria to mammalian cells. This reveals that a near-adder behavior is the most common type of size control and highlights the importance of growth rate modulation to size control in mammalian cells. | eng |
dc.description.version | publishedVersion | eng |
dc.format | application/pdf | |
dc.identifier.uri | https://doi.org/10.34657/445 | |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/4622 | |
dc.language.iso | eng | eng |
dc.publisher | London : Nature Publishing Group | eng |
dc.relation.doi | https://doi.org/10.1038/s41467-018-05393-0 | |
dc.relation.ispartofseries | Nature Communications | eng |
dc.rights.license | CC BY 4.0 Unported | eng |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | eng |
dc.subject.ddc | 570 | eng |
dc.title | Size control in mammalian cells involves modulation of both growth rate and cell cycle duration | eng |
dc.type | article | eng |
dc.type | Text | eng |
dcterms.bibliographicCitation.journalTitle | Nature Communications | eng |
tib.accessRights | openAccess | eng |
wgl.contributor | INM | eng |
wgl.subject | Biowissenschaften/Biologie | eng |
wgl.type | Zeitschriftenartikel | eng |
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