Laccase-catalyzed derivatization of antibiotics with sulfonamide or sulfone structures

dc.bibliographicCitation.firstPage2199
dc.bibliographicCitation.issue11
dc.bibliographicCitation.journalTitleMicroorganismseng
dc.bibliographicCitation.volume9
dc.contributor.authorMikolasch, Annett
dc.contributor.authorHahn, Veronika
dc.date.accessioned2023-05-22T07:20:03Z
dc.date.available2023-05-22T07:20:03Z
dc.date.issued2021
dc.description.abstractTrametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of antibiotics with sulfonamide or sulfone structures with 2,5-dihydroxybenzene derivatives to form new heterodimers and heterotrimers. These heteromolecular hybrid products are formed by nuclear amination of the p-hydroquinones with the primary amino group of the sulfonamide or sulfone antibiotics, and they inhibited in vitro the growth of Staphylococcus species, including multidrug-resistant strains.eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/12166
dc.identifier.urihttp://dx.doi.org/10.34657/11199
dc.language.isoeng
dc.publisherBasel : MDPI
dc.relation.doihttps://doi.org/10.3390/microorganisms9112199
dc.relation.essn2076-2607
dc.rights.licenseCC BY 4.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subject.ddc570
dc.subject.otherAntibacterial activityeng
dc.subject.otherAntimicrobial resistance (AMR)eng
dc.subject.otherBiotransformationeng
dc.subject.otherLaccaseeng
dc.subject.otherMethicillin-resistant Staphylococcus aureus (MRSA)eng
dc.subject.otherMultidrug resistance (MDR)eng
dc.subject.otherSulfonamide antibioticseng
dc.subject.otherβ-lactam antibioticseng
dc.titleLaccase-catalyzed derivatization of antibiotics with sulfonamide or sulfone structureseng
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccess
wgl.contributorINP
wgl.subjectBiowissenschaften/Biologieger
wgl.typeZeitschriftenartikelger
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