Timing cellular decision making under noise via cell-cell communication
dc.bibliographicCitation.firstPage | e4872 | eng |
dc.bibliographicCitation.issue | 3 | eng |
dc.bibliographicCitation.journalTitle | PLoS ONE | eng |
dc.bibliographicCitation.volume | 4 | eng |
dc.contributor.author | Koseska, A. | |
dc.contributor.author | Zaikin, A. | |
dc.contributor.author | Kurths, J. | |
dc.contributor.author | García-Ojalvo, J. | |
dc.date.accessioned | 2020-08-03T06:36:56Z | |
dc.date.available | 2020-08-03T06:36:56Z | |
dc.date.issued | 2009 | |
dc.description.abstract | Many cellular processes require decision making mechanisms, which must act reliably even in the unavoidable presence of substantial amounts of noise. However, the multistable genetic switches that underlie most decision-making processes are dominated by fluctuations that can induce random jumps between alternative cellular states. Here we show, via theoretical modeling of a population of noise-driven bistable genetic switches, that reliable timing of decision-making processes can be accomplished for large enough population sizes, as long as cells are globally coupled by chemical means. In the light of these results, we conjecture that cell proliferation, in the presence of cell-cell communication, could provide a mechanism for reliable decision making in the presence of noise, by triggering cellular transitions only when the whole cell population reaches a certain size. In other words, the summation performed by the cell population would average out the noise and reduce its detrimental impact. | eng |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://doi.org/10.34657/4000 | |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/5371 | |
dc.language.iso | eng | eng |
dc.publisher | San Francisco, CA : Public Library of Science (PLoS) | eng |
dc.relation.doi | https://doi.org/10.1371/journal.pone.0004872 | |
dc.relation.issn | 1932-6203 | |
dc.rights.license | CC BY 3.0 Unported | eng |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | eng |
dc.subject.ddc | 570 | eng |
dc.subject.other | article | eng |
dc.subject.other | cell communication | eng |
dc.subject.other | cell damage | eng |
dc.subject.other | cell function | eng |
dc.subject.other | cell population | eng |
dc.subject.other | cell proliferation | eng |
dc.subject.other | cell size | eng |
dc.subject.other | controlled study | eng |
dc.subject.other | gene switching | eng |
dc.subject.other | noise | eng |
dc.subject.other | oscillation | eng |
dc.subject.other | population size | eng |
dc.subject.other | theoretical model | eng |
dc.subject.other | whole cell | eng |
dc.subject.other | biological model | eng |
dc.subject.other | biological rhythm | eng |
dc.subject.other | cellular, subcellular and molecular biological phenomena and functions | eng |
dc.subject.other | cytology | eng |
dc.subject.other | prokaryotic cell | eng |
dc.subject.other | statistics | eng |
dc.subject.other | time | eng |
dc.subject.other | Biological Clocks | eng |
dc.subject.other | Cell Communication | eng |
dc.subject.other | Cell Physiological Processes | eng |
dc.subject.other | Models, Biological | eng |
dc.subject.other | Prokaryotic Cells | eng |
dc.subject.other | Stochastic Processes | eng |
dc.subject.other | Time Factors | eng |
dc.title | Timing cellular decision making under noise via cell-cell communication | eng |
dc.type | Article | eng |
dc.type | Text | eng |
tib.accessRights | openAccess | eng |
wgl.contributor | PIK | eng |
wgl.subject | Biowissenschaften/Biologie | eng |
wgl.type | Zeitschriftenartikel | eng |
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