Presence of β-Lactamase-producing Enterobacterales and Salmonella Isolates in Marine Mammals
dc.bibliographicCitation.firstPage | 5905 | eng |
dc.bibliographicCitation.issue | 11 | eng |
dc.bibliographicCitation.journalTitle | International journal of molecular sciences | eng |
dc.bibliographicCitation.volume | 22 | eng |
dc.contributor.author | Grünzweil, Olivia M. | |
dc.contributor.author | Palmer, Lauren | |
dc.contributor.author | Cabal, Adriana | |
dc.contributor.author | Szostak, Michael P. | |
dc.contributor.author | Ruppitsch, Werner | |
dc.contributor.author | Kornschober, Christian | |
dc.contributor.author | Korus, Maciej | |
dc.contributor.author | Misic, Dusan | |
dc.contributor.author | Bernreiter-Hofer, Tanja | |
dc.contributor.author | Korath, Anna D. J. | |
dc.contributor.author | Feßler, Andrea T. | |
dc.contributor.author | Allerberger, Franz | |
dc.contributor.author | Schwarz, Stefan | |
dc.contributor.author | Spergser, Joachim | |
dc.contributor.author | Müller, Elke | |
dc.contributor.author | Braun, Sascha D. | |
dc.contributor.author | Monecke, Stefan | |
dc.contributor.author | Ehricht, Ralf | |
dc.contributor.author | Walzer, Chris | |
dc.contributor.author | Smodlaka, Hrvoje | |
dc.contributor.author | Loncaric, Igor | |
dc.date.accessioned | 2022-03-04T07:33:22Z | |
dc.date.available | 2022-03-04T07:33:22Z | |
dc.date.issued | 2021 | |
dc.description.abstract | Marine mammals have been described as sentinels of the health of marine ecosystems. Therefore, the aim of this study was to investigate (i) the presence of extended-spectrum β-lactamase (ESBL)- and AmpC-producing Enterobacterales, which comprise several bacterial families important to the healthcare sector, as well as (ii) the presence of Salmonella in these coastal animals. The antimicrobial resistance pheno- and genotypes, as well as biocide susceptibility of Enterobacterales isolated from stranded marine mammals, were determined prior to their rehabilitation. All E. coli isolates (n = 27) were screened for virulence genes via DNA-based microarray, and twelve selected E. coli isolates were analyzed by whole-genome sequencing. Seventy-one percent of the Enterobacterales isolates exhibited a multidrug-resistant (MDR) pheno- and genotype. The gene blaCMY (n = 51) was the predominant β-lactamase gene. In addition, blaTEM-1 (n = 38), blaSHV-33 (n = 8), blaCTX-M-15 (n = 7), blaOXA-1 (n = 7), blaSHV-11 (n = 3), and blaDHA-1 (n = 2) were detected. The most prevalent non-β-lactamase genes were sul2 (n = 38), strA (n = 34), strB (n = 34), and tet(A) (n = 34). Escherichia coli isolates belonging to the pandemic sequence types (STs) ST38, ST167, and ST648 were identified. Among Salmonella isolates (n = 18), S. Havana was the most prevalent serotype. The present study revealed a high prevalence of MDR bacteria and the presence of pandemic high-risk clones, both of which are indicators of anthropogenic antimicrobial pollution, in marine mammals. | eng |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/8152 | |
dc.identifier.uri | https://doi.org/10.34657/7192 | |
dc.language.iso | eng | eng |
dc.publisher | Basel : Molecular Diversity Preservation International (MDPI) | eng |
dc.relation.doi | https://doi.org/10.3390/ijms22115905 | |
dc.relation.essn | 1422-0067 | |
dc.rights.license | CC BY 4.0 Unported | eng |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | eng |
dc.subject.ddc | 570 | eng |
dc.subject.ddc | 540 | eng |
dc.subject.other | Antimicrobial resistance | eng |
dc.subject.other | E. coli | eng |
dc.subject.other | ESBL/AmpC | eng |
dc.subject.other | K. pneumoniae | eng |
dc.subject.other | Wildlife | eng |
dc.title | Presence of β-Lactamase-producing Enterobacterales and Salmonella Isolates in Marine Mammals | eng |
dc.type | Article | eng |
dc.type | Text | eng |
tib.accessRights | openAccess | eng |
wgl.contributor | IPHT | eng |
wgl.subject | Biowissensschaften/Biologie | eng |
wgl.type | Zeitschriftenartikel | eng |
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