Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering

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dc.bibliographicCitation.firstPage560
dc.bibliographicCitation.issue7
dc.bibliographicCitation.journalTitleMaterialseng
dc.bibliographicCitation.volume9
dc.contributor.authorHardy, John G.
dc.contributor.authorTorres-Rendon, Jose Guillermo
dc.contributor.authorLeal-Egaña, Aldo
dc.contributor.authorWalther, Andreas
dc.contributor.authorSchlaad, Helmut
dc.contributor.authorCölfen, Helmut
dc.contributor.authorScheibel, Thomas
dc.date.accessioned2023-01-24T10:35:11Z
dc.date.available2023-01-24T10:35:11Z
dc.date.issued2016
dc.description.abstractMaterials based on biodegradable polyesters, such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT), have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein, the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate is reported. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue engineering.eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/11019
dc.identifier.urihttp://dx.doi.org/10.34657/10045
dc.language.isoeng
dc.publisherBasel : MDPI
dc.relation.doihttps://doi.org/10.3390/ma9070560
dc.relation.essn1996-1944
dc.rights.licenseCC BY 4.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ddc600
dc.subject.otherBiodegradable polymerseng
dc.subject.otherBiomaterialseng
dc.subject.otherBiomineralizationeng
dc.subject.otherBone tissue engineeringeng
dc.subject.otherRecombinant proteineng
dc.subject.otherSpider silkeng
dc.titleBiomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineeringeng
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccess
wgl.contributorDWI
wgl.subjectChemieger
wgl.typeZeitschriftenartikelger
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