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search.filters.applied.f.access: openAccess × Author: Voelcker, Nicolas H. × End date: 2019 × End date: 2018 × Start date: 2010 × DDC: 610 × Type: Text × WGL Institute: INM ×

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    Surface-assisted laser desorption/ionization mass spectrometry using ordered silicon nanopillar arrays
    (Cambridge : Royal Society of Chemistry, 2014) Alhmoud, Hashim Z.; Guinan, Taryn M.; Elnathan, Roey; Kobus, Hilton; Voelcker, Nicolas H.
    Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is ideally suited for the high-throughput analysis of small molecules in bodily fluids (e.g. saliva, urine, and blood plasma). A key application for this technique is the testing of drug consumption in the context of workplace, roadside, athlete sports and anti-addictive drug compliance. Here, we show that vertically-aligned ordered silicon nanopillar (SiNP) arrays fabricated using nanosphere lithography followed by metal-assisted chemical etching (MACE) are suitable substrates for the SALDI-MS detection of methadone and small peptides. Porosity, length and diameter are fabrication parameters that we have explored here in order to optimize analytical performance. We demonstrate the quantitative analysis of methadone in MilliQ water down to 32 ng mL-1. Finally, the capability of SiNP arrays to facilitate the detection of methadone in clinical samples is also demonstrated.
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    Gradients of Al/Al2O3 nanostructures for screening mesenchymal stem cell proliferation and differentiation
    (Wuhan : Scientific Research Publishing, 2013) Veith, Michael; Dufloux, Cécile; Ghaemi, Soraya Rasi; Cenk, Aktas; Voelcker, Nicolas H.
    By decomposing a molecular precursor we fabricated a novel surface based on an aluminium/aluminiumoxide composite incorporating nanotopography gradient to address high-throughput and fast analysis method for studying stem cell differentiation by nanostructures. Depending on the topography of the nanostructures, mesenchymal stem cells exhibit a diverse proliferation and differentiation behavior.