1860 results
Search Results
Now showing 1 - 10 of 1860
- ItemEffects of (complementary) polyelectrolytes characteristics on composite calcium carbonate microparticles properties(BucureÅŸti : [Verlag nicht ermittelbar], 2017) Mic, Cristian Barbu; Mihai, Marcela; Varganici, Cristian Dragos; Schwarz, Simona; Scutaru, Dan; Simionescu, Bogdan C.This study follows the possibility to tune the thermal stability of some CaCO3/polymer composites by crystal growth from supersaturated solutions controlled by polymer structure or by using nonstoichiometric polyelectrolyte complexes (NPECs). As the ratio between the organic and inorganic parts in the composites controls the Ca2+/polymer network crosslinking density, the CaCO3/polymer weight ratio was kept constant at 50/1, varying the initial concentration of the polyanions solutions (0.05 or 0.06 wt.%), the NPECs molar ratio , n+/n- (0.2 or 0.4), or the inorganic precursors concentration (0.25 or 0.3 M). Poly(2-acrylamido-2-methylpropanesulfonic acid-co-acrylic acid) (PSA) and chondroitin-4-sulfate (CSA) were used as polyanions. Some NPEC dispersions, prepared with the same polyanions and poly(allylamine hydrochloride) (PAH), were also used for calcium carbonate crystallization. The characteristics of the prepared composites were investigated by scanning electron microscopy (SEM), flow particle image analysis (FPIA), particles charge density (CD), zeta-potential (ZP). The thermal stability of the composite particles was investigated as compared to bare CaCO3 microparticles prepared at the same initial inorganic concentrations.
- ItemA new bifunctional hybrid nanostructure as an active platform for photothermal therapy and MR imaging(London : Nature Publishing Group, 2016) Khafaji, Mona; Vossoughi, Manouchehr; Hormozi-Nezhad, M. Reza; Dinarvand, Rassoul; Börrnert, Felix; Irajizad, AzamAs a bi-functional cancer treatment agent, a new hybrid nanostructure is presented which can be used for photothermal therapy by exposure to one order of magnitude lower laser powers compared to similar nanostructures in addition to substantial enhancment in magnetic resonance imaging (MRI) contrast. This gold-iron oxide hybrid nanostructure (GIHN) is synthesized by a cost-effective and high yield water-based approach. The GIHN is sheilded by PEG. Therefore, it shows high hemo and biocompatibility and more than six month stability. Alongside earlier nanostructures, the heat generation rate of GIHN is compareable with surfactnat-capped gold nanorods (GNRs). Two reasons are behind this enhancement: Firstly the distance between GNRs and SPIONs is adjusted in a way that the surface plasmon resonance of the new nanostructure is similar to bare GNRs and secondly the fraction of GNRs is raised in the hybrid nanostructure. GIHN is then applied as a photothermal agent using laser irradiation with power as low as 0.5 W.cm−2 and only 32% of human breast adenocarcinoma cells could survive. The GIHN also acts as a dose-dependent transvers relaxation time (T2) MRI contrast agent. The results show that the GINH can be considered as a good candidate for multimodal photothermal therapy and MRI.
- ItemEfficient coupling of inhomogeneous current spreading and dynamic electro-optical models for broad-area edge-emitting semiconductor devices(Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2017) Radziunas, Mindaugas; Zeghuzi, Anissa; Fuhrmann, Jürgen; Koprucki, Thomas; Wünsche, Hans-Jürgen; Wenzel, Hans; Bandelow, UweWe extend a 2 (space) + 1 (time)-dimensional traveling wave model for broad-area edgeemitting semiconductor lasers by a model for inhomogeneous current spreading from the contact to the active zone of the laser. To speedup the performance of the device simulations, we suggest and discuss several approximations of the inhomogeneous current density in the active zone.
- ItemMechanics of Materials: Mechanics of Interfaces and Evolving Microstructure(Zürich : EMS Publ. House, 2016) McDowell, David L.; Müller, Stefan; Werner, Ewald A.Emphasis in modern day efforts in mechanics of materials is increasingly directed towards integration with computational materials science, which itself rests on solid physical and mathematical foundations in thermodynamics and kinetics of processes. Practical applications demand attention to length and time scales which are sufficiently large to preclude direct application of quantum mechanics approaches; accordingly, there are numerous pathways to mathematical modelling of the complexity of material structure during processing and in service. The conventional mathematical machinery of energy minimization provides guidance but has limited direct applicability to material systems evolving away from equilibrium. Material response depends on driving forces, whether arising from mechanical, electromagnetic, or thermal fields. When microstructures evolve, as during plastic deformation, progressive damage and fracture, corrosion, stress-assisted diffusion, migration or chemical/thermal aging, the associated classical mathematical frameworks are often ad hoc and heuristic. Advancing new and improved methods is a major focus of 21st century mechanics of materials of interfaces and evolving microstructure.
- ItemEffect of Alloying Elements in Melt Spun Mg-alloys for Hydrogen Storage(São Carlos : SciELO - Scientific Electronic Library Online, 2016) Rozenberg, Silvia; Saporiti, Fabiana; Lang, Julien; Audebert, Fernando; Botta, Pablo; Stoica, Mihai; Huot, Jacques; Eckert, JürgenIn this paper we report the effect of alloying elements on hydrogen storage properties of melt-spun Mg-based alloys. The base alloys Mg90Si10, Mg90Cu10, Mg65Cu35 (at%) were studied. We also investigated the effect of rare earths (using MM: mischmetal) and Al in Mg65Cu25Al10, Mg65Cu25MM10 and Mg65Cu10Al15MM10 alloys. All the melt-spun alloys without MM show a crystalline structure, and the Mg65Cu25MM10 and Mg65Cu10Al15MM10 alloys showed an amorphous and partially amorphous structure respectively. At 350˚C all the alloys had a crystalline structure during the hydrogen absorption-desorption tests. It was observed that Si and Cu in the binaries alloys hindered completely the activation of the hydrogen absorption. The partial substitution of Cu by MM or Al allowed activation. The combined substitution of Cu by MM and Al showed the best results with the fastest absorption and desorption kinetics, which suggests that this combination can be used for new Mg-alloys to improve hydrogen storage properties.
- ItemNesting-driven multipolar order in CeB6 from photoemission tomography(London : Nature Publishing Group, 2016) Koitzsch, A.; Heming, N.; Knupfer, M.; Büchner, B.; Portnichenko, P.Y.; Dukhnenko, A.V.; Shitsevalova, N.Y.; Filipov, V.B.; Lev, L.L.Some heavy fermion materials show so-called hidden-order phases which are invisible to many characterization techniques and whose microscopic origin remained controversial for decades. Among such hidden-order compounds, CeB6 is of model character due to its simple electronic configuration and crystal structure. Apart from more conventional antiferromagnetism, it shows an elusive phase at low temperatures, which is commonly associated with multipolar order. Here we show that this phase roots in a Fermi surface instability. This conclusion is based on a full 3D tomographic sampling of the electronic structure by angle-resolved photoemission and comparison with inelastic neutron scattering data. The hidden order is mediated by itinerant electrons. Our measurements will serve as a paradigm for the investigation of hidden-order phases in f-electron systems, but also generally for situations where the itinerant electrons drive orbital or spin order.
- ItemSugar-Modified Poly(propylene imine) Dendrimers Stimulate the NF-κB Pathway in a Myeloid Cell Line(Dordrecht [u.a.] : Springer Science + Business Media B.V, 2016) Jatczak-Pawlik, Izabela; Gorzkiewicz, Michal; Studzian, Maciej; Appelhans, Dietmar; Voit, Brigitte; Pulaski, Lukasz; Klajnert-Maculewicz, BarbaraPurpose: Fourth-generation poly(propylene imine) dendrimers fully surface-modified by maltose (dense shell, PPI-m DS) were shown to be biocompatible in cellular models, which is important for their application in drug delivery. We decided to verify also their inherent bioactivity, including immunomodulatory activity, for potential clinical applications. We tested their effects on the THP-1 monocytic cell line model of innate immunity effectors. Methods: To estimate the cytotoxicity of dendrimers the reasazurin assay was performed. The expression level of NF-κB targets: IGFBP3, TNFAIP3 and TNF was determined by quantitative real-time RT-PCR. Measurement of NF-κB p65 translocation from cytoplasm to nucleus was conducted with a high-content screening platform and binding of NF-κB to a consensus DNA probe was determined by electrophoretic mobility shift assay. The cytokine assay was performed to measure protein concentration of TNFalpha and IL-4. Results: We found that PPI-m DS did not impact THP-1 viability and growth even at high concentrations (up to 100 μM). They also did not induce expression of genes for important signaling pathways: Jak/STAT, Keap1/Nrf2 and ER stress. However, high concentrations of 4th generation PPI-m DS (25–100 μM), but not their 3rd generation counterparts, induced nuclear translocation of p65 NF-κB protein and its DNA-binding activity, leading to NF-κB-dependent increased expression of mRNA for NF-κB targets: IGFBP3, TNFAIP3 and TNF. However, no increase in pro-inflammatory cytokine secretion was detected. Conclusion: We conclude that maltose-modified PPI dendrimers of specific size could exert a modest immunomodulatory effect, which may be advantageous in clinical applications (e.g. adjuvant effect in anti-cancer vaccines).
- ItemYet another algorithm for the symmetric eigenvalue problem(Oberwolfach : Mathematisches Forschungsinstitut Oberwolfach, 2016) Aurentz, Jared L.; Mach, Thomas; Vandebril, Raf; Watkins, David S.In this paper we present a new algorithm for solving the symmetric matrix eigenvalue problem that works by first using a Cayley transformation to convert the symmetric matrix into a unitary one and then uses Gragg’s implicitly shifted unitary QR algorithm to solve the resulting unitary eigenvalue problem. We prove that under reasonable assumptions on the symmetric matrix this algorithm is backward stable and also demonstrate that this algorithm is comparable with other well known implementations in terms of both speed and accuracy.
- ItemInner solar system material discovered in the Oort cloud(Washington, DC [u.a.] : Assoc., 2016) Meech, Karen J.; Yang, Bin; Kleyna, Jan; Hainaut, Olivier R.; Berdyugina, Svetlana; Keane, Jacqueline V.; Micheli, Marco; Morbidelli, Alessandro; Wainscoat, Richard J.We have observed C/2014 S3 (PANSTARRS), a recently discovered object on a cometary orbit coming from the Oort cloud that is physically similar to an inner main belt rocky S-type asteroid. Recent dynamical models successfully reproduce the key characteristics of our current solar system; some of these models require significant migration of the giant planets, whereas others do not. These models provide different predictions on the presence of rocky material expelled from the inner solar system in the Oort cloud. C/2014 S3 could be the key to verifying these predictions of the migration-based dynamical models. Furthermore, this object displays a very faint, weak level of comet-like activity, five to six orders of magnitude less than that of typical ice-rich comets on similar Orbits coming from the Oort cloud. For the nearly tailless appearance, we are calling C/2014 S3 a Manx object. Various arguments convince us that this activity is produced by sublimation of volatile ice, that is, normal cometary activity. The activity implies that C/2014 S3 has retained a tiny fraction of the water that is expected to be present at its formation distance in the inner solar system. We may be looking at fresh inner solar system Earth-forming material that was ejected from the inner solar system and preserved for billions of years in the Oort cloud.
- ItemSprints und kollaboratives Wissensmanagement im Confluence-Wiki der Technischen Informationsbibliothek(Reutlingen : Berufsverband Information Bibliothek e. V., 2017) Strobel, SvenSoziale Softwarewerkzeuge wie Wikis sind in Unternehmen und auch im Bibliotheksbereich längst etabliert. Sie unterstützen das Projekt- und Wissensmanagement der Organisation. Häufig werden die Möglichkeiten, die diese Techniken bieten, allerdings nicht voll ausgeschöpft. Dieser Beitrag zeigt anhand eines Projekts der Technischen Informationsbibliothek (TIB), wie wesentlich das Unternehmenswiki das Wissensmanagement und kollaborative Arbeiten in Projekten unterstützen kann, wenn es intensiv genutzt wird. Die TIB musste nicht erst eine teure und komplizierte Software hinzukaufen, sondern setzte auf das im Haus bereits etablierte Confluence-Wiki. Confluence ist ein Standard-Tool, das in vielen Bibliotheken verwendet wird. Das TIB-Projekt hatte zum Ziel, den Relaunch des AV-Portals (av.tib.eu) zu organisieren. Das Team integrierte in seine Projektarbeit ein Konzept aus dem agilen Produktmanagement: sog. Sprints“. Diese Sprints wurden mit einem differenzierten und rollenbasierten Prozess im Confluence-Wiki abgebildet. In dem von der TIB entwickelten Sprint-Konzept legt der Projektmanager ein Dokument im Wiki an, in dem er erste Anforderungen und Aufgaben für alle Teammitglieder festhält. Die Teammitglieder schreiben das Konzept kollaborativ auf einer Wiki-Seite und arbeiten ihre Aufgaben ab. Der Projektmanager nutzt das Wiki, um Konzeptfortschritt und Aufgabenbearbeitung zu kontrollieren. Sprints liefern am Ende Konzepte, die kollaborativ evaluiert, entwickelt und abgenommen wurden. Sie vereinfachen und beschleunigen komplexe Entscheidungsfindungen und lassen sich in zahlreichen Bereichen des Projekt- und Wissensmanagements anwenden. Der Beitrag stellt Ablauf, Rollen und Dokumente des TIB-Sprint-Workflows detailliert vor.