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- ItemGraphene oxide functional nanohybrids with magnetic nanoparticles for improved vectorization of doxorubicin to neuroblastoma cells(Basel : MDPI AG, 2019) Lerra, L.; Farfalla, A.; Sanz, B.; Cirillo, G.; Vittorio, O.; Voli, F.; Grand, M.L.; Curcio, M.; Nicoletta, F.P.; Dubrovska, A.; Hampel, S.; Iemma, F.; Goya, G.F.With the aim to obtain a site-specific doxorubicin (DOX) delivery in neuroblastoma SH-SY5Y cells, we designed an hybrid nanocarrier combining graphene oxide (GO) and magnetic iron oxide nanoparticles (MNPs), acting as core elements, and a curcumin–human serum albumin conjugate as functional coating. The nanohybrid, synthesized by redox reaction between the MNPs@GO system and albumin bioconjugate, consisted of MNPs@GO nanosheets homogeneously coated by the bioconjugate as verified by SEM investigations. Drug release experiments showed a pH-responsive behavior with higher release amounts in acidic (45% at pH 5.0) vs. neutral (28% at pH 7.4) environments. Cell internalization studies proved the presence of nanohybrid inside SH-SY5Y cytoplasm. The improved efficacy obtained in viability assays is given by the synergy of functional coating and MNPs constituting the nanohybrids: while curcumin moieties were able to keep low DOX cytotoxicity levels (at concentrations of 0.44–0.88 µM), the presence of MNPs allowed remote actuation on the nanohybrid by a magnetic field, increasing the dose delivered at the target site.
- ItemSwitchable magnetic bulk photovoltaic effect in the two-dimensional magnet CrI3(London : Nature Publishing Group, 2019) Zhang, Y.; Holder, T.; Ishizuka, H.; de Juan, F.; Nagaosa, N.; Felser, C.; Yan, B.The bulk photovoltaic effect (BPVE) rectifies light into the dc current in a single-phase material and attracts the interest to design high-efficiency solar cells beyond the pn junction paradigm. Because it is a hot electron effect, the BPVE surpasses the thermodynamic Shockley–Queisser limit to generate above-band-gap photovoltage. While the guiding principle for BPVE materials is to break the crystal centrosymmetry, here we propose a magnetic photogalvanic effect (MPGE) that introduces the magnetism as a key ingredient and induces a giant BPVE. The MPGE emerges from the magnetism-induced asymmetry of the carrier velocity in the band structure. We demonstrate the MPGE in a layered magnetic insulator CrI3, with much larger photoconductivity than any previously reported results. The photocurrent can be reversed and switched by controllable magnetic transitions. Our work paves a pathway to search for magnetic photovoltaic materials and to design switchable devices combining magnetic, electronic, and optical functionalities.
- ItemState-of-the-art global models underestimate impacts from climate extremes([London] : Nature Publishing Group UK, 2019) Schewe, Jacob; Gosling, Simon N.; Reyer, Christopher; Zhao, Fang; Ciais, Philippe; Elliott, Joshua; Francois, Louis; Huber, Veronika; Lotze, Heike K.; Seneviratne, Sonia I.; van Vliet, Michelle T. H.; Vautard, Robert; Wada, Yoshihide; Breuer, Lutz; Büchner, Matthias; Carozza, David A.; Chang, Jinfeng; Coll, Marta; Deryng, Delphine; de Wit, Allard; Eddy, Tyler D.; Folberth, Christian; Frieler, Katja; Friend, Andrew D.; Gerten, Dieter; Gudmundsson, Lukas; Hanasaki, Naota; Ito, Akihiko; Khabarov, Nikolay; Kim, Hyungjun; Lawrence, Peter; Morfopoulos, Catherine; Müller, Christoph; Müller Schmied, Hannes; Orth, René; Ostberg, Sebastian; Pokhrel, Yadu; Pugh, Thomas A. M.; Sakurai, Gen; Satoh, Yusuke; Schmid, Erwin; Stacke, Tobias; Steenbeek, Jeroen; Steinkamp, Jörg; Tang, Qiuhong; Tian, Hanqin; Tittensor, Derek P.; Volkholz, Jan; Wang, Xuhui; Warszawski, LilaGlobal impact models represent process-level understanding of how natural and human systems may be affected by climate change. Their projections are used in integrated assessments of climate change. Here we test, for the first time, systematically across many important systems, how well such impact models capture the impacts of extreme climate conditions. Using the 2003 European heat wave and drought as a historical analogue for comparable events in the future, we find that a majority of models underestimate the extremeness of impacts in important sectors such as agriculture, terrestrial ecosystems, and heat-related human mortality, while impacts on water resources and hydropower are overestimated in some river basins; and the spread across models is often large. This has important implications for economic assessments of climate change impacts that rely on these models. It also means that societal risks from future extreme events may be greater than previously thought.
- ItemEnvironmental co-benefits and adverse side-effects of alternative power sector decarbonization strategies([London] : Nature Publishing Group UK, 2019) Luderer, Gunnar; Pehl, Michaja; Arvesen, Anders; Gibon, Thomas; Bodirsky, Benjamin L.; de Boer, Harmen Sytze; Fricko, Oliver; Hejazi, Mohamad; Humpenöder, Florian; Iyer, Gokul; Mima, Silvana; Mouratiadou, Ioanna; Pietzcker, Robert C.; Popp, Alexander; van den Berg, Maarten; van Vuuren, Detlef; Hertwich, Edgar G.A rapid and deep decarbonization of power supply worldwide is required to limit global warming to well below 2 °C. Beyond greenhouse gas emissions, the power sector is also responsible for numerous other environmental impacts. Here we combine scenarios from integrated assessment models with a forward-looking life-cycle assessment to explore how alternative technology choices in power sector decarbonization pathways compare in terms of non-climate environmental impacts at the system level. While all decarbonization pathways yield major environmental co-benefits, we find that the scale of co-benefits as well as profiles of adverse side-effects depend strongly on technology choice. Mitigation scenarios focusing on wind and solar power are more effective in reducing human health impacts compared to those with low renewable energy, while inducing a more pronounced shift away from fossil and toward mineral resource depletion. Conversely, non-climate ecosystem damages are highly uncertain but tend to increase, chiefly due to land requirements for bioenergy.
- ItemKey determinants of global land-use projections([London] : Nature Publishing Group UK, 2019) Stehfest, Elke; van Zeist, Willem-Jan; Valin, Hugo; Havlik, Petr; Popp, Alexander; Kyle, Page; Tabeau, Andrzej; Mason-D’Croz, Daniel; Hasegawa, Tomoko; Bodirsky, Benjamin L.; Calvin, Katherine; Doelman, Jonathan C.; Fujimori, Shinichiro; Humpenöder, Florian; Lotze-Campen, Hermann; van Meijl, Hans; Wiebe, KeithLand use is at the core of various sustainable development goals. Long-term climate foresight studies have structured their recent analyses around five socio-economic pathways (SSPs), with consistent storylines of future macroeconomic and societal developments; however, model quantification of these scenarios shows substantial heterogeneity in land-use projections. Here we build on a recently developed sensitivity approach to identify how future land use depends on six distinct socio-economic drivers (population, wealth, consumption preferences, agricultural productivity, land-use regulation, and trade) and their interactions. Spread across models arises mostly from diverging sensitivities to long-term drivers and from various representations of land-use regulation and trade, calling for reconciliation efforts and more empirical research. Most influential determinants for future cropland and pasture extent are population and agricultural efficiency. Furthermore, land-use regulation and consumption changes can play a key role in reducing both land use and food-security risks, and need to be central elements in sustainable development strategies.
- ItemShared MRSA Strains among Nepalese Rhesus macaques (Macaca mulatta), their Environment and Hospitalized Patients(Lausanne : Frontiers Media, 2019) Roberts, Marilyn C.; Joshi, Prabhu Raj; Monecke, Stefan; Ehricht, Ralf; Müller, Elke; Gawlik, Darius; Paudel, Saroj; Acharya, Mahesh; Bhattarai, Sankalpa; Pokharel, Sujana; Tuladhar, Reshma; Chalise, Mukesh K.; Kyes, Randall C.This study looked at 227 saliva samples from Rhesus macaques (Macaca mulatta) and 218 samples from the surrounding environments. From these samples, MRSA isolates were collected from Rhesus saliva samples (n = 13) and environmental samples (n = 19) near temple areas in Kathmandu, Nepal. For comparison, selected MRSA isolates (n = 5) were obtained from patients with wound infections from a Kathmandu hospital. All isolates were characterized using Abbott StaphyType® DNA microarrays. Eighteen isolates (62%) from monkeys (n = 4; 31%) and environmental samples (n = 14; 74%), were CC22-MRSA-IV. Most (n = 16) of them carried both, the PVL locus and toxic shock toxin gene (tst1), an unusual combination which is the same as in previously characterized strain from Nepalese macaques and pigs. The five human isolates also belonged to that strain type. Eight monkey MRSA isolates were CC361-MRSA-IV. One MRSA from a monkey and one from an environmental sample, were CC88-MRSA-V. Other environmental MRSA included one each, CC121-MRSA-VT, and CC772 -MRSA-V. Two were CC779-MRSA-VT, potentially a novel clone. All MRSA carried the blaZ gene. The aacA–aphD, dfrA, and erm (C) genes were very common in isolates from all sources. One macaque MRSA carried the resistance genes aphA3 and sat, neither previously identified in primate MRSA isolates. This current study suggests that humans could be a potential source of the MRSA in the macaques/environment and transmission may be linked to humans feeding the primates and/or living in close proximity to each other.This study looked at 227 saliva samples from Rhesus macaques (Macaca mulatta) and 218 samples from the surrounding environments. From these samples, MRSA isolates were collected from Rhesus saliva samples (n = 13) and environmental samples (n = 19) near temple areas in Kathmandu, Nepal. For comparison, selected MRSA isolates (n = 5) were obtained from patients with wound infections from a Kathmandu hospital. All isolates were characterized using Abbott StaphyType® DNA microarrays. Eighteen isolates (62%) from monkeys (n = 4; 31%) and environmental samples (n = 14; 74%), were CC22-MRSA-IV. Most (n = 16) of them carried both, the PVL locus and toxic shock toxin gene (tst1), an unusual combination which is the same as in previously characterized strain from Nepalese macaques and pigs. The five human isolates also belonged to that strain type. Eight monkey MRSA isolates were CC361-MRSA-IV. One MRSA from a monkey and one from an environmental sample, were CC88-MRSA-V. Other environmental MRSA included one each, CC121-MRSA-VT, and CC772 -MRSA-V. Two were CC779-MRSA-VT, potentially a novel clone. All MRSA carried the blaZ gene. The aacA–aphD, dfrA, and erm (C) genes were very common in isolates from all sources. One macaque MRSA carried the resistance genes aphA3 and sat, neither previously identified in primate MRSA isolates. This current study suggests that humans could be a potential source of the MRSA in the macaques/environment and transmission may be linked to humans feeding the primates and/or living in close proximity to each other.
- ItemAdvanced Signal Processing and Adaptive Learning Methods(New York, NY [u.a.] : Hindawi Publ. Corp., 2019) Delić, Vlado; Stamenković, Zoran; Pokrajac, David[No abstract available]
- ItemColiCoords: A Python package for the analysis of bacterial fluorescence microscopy data(San Francisco, California, US : PLOS, 2019) Smit, Jochem H.; Li, Yichen; Warszawik, Eliza M.; Herrmann, Andreas; Cordes, Thorben; Gilestro, Giorgio FSingle-molecule fluorescence microscopy studies of bacteria provide unique insights into the mechanisms of cellular processes and protein machineries in ways that are unrivalled by any other technique. With the cost of microscopes dropping and the availability of fully automated microscopes, the volume of microscopy data produced has increased tremendously. These developments have moved the bottleneck of throughput from image acquisition and sample preparation to data analysis. Furthermore, requirements for analysis procedures have become more stringent given the demand of various journals to make data and analysis procedures available. To address these issues we have developed a new data analysis package for analysis of fluorescence microscopy data from rod-like cells. Our software ColiCoords structures microscopy data at the single-cell level and implements a coordinate system describing each cell. This allows for the transformation of Cartesian coordinates from transmission light and fluorescence images and single-molecule localization microscopy (SMLM) data to cellular coordinates. Using this transformation, many cells can be combined to increase the statistical power of fluorescence microscopy datasets of any kind. ColiCoords is open source, implemented in the programming language Python, and is extensively documented. This allows for modifications for specific needs or to inspect and publish data analysis procedures. By providing a format that allows for easy sharing of code and associated data, we intend to promote open and reproducible research. The source code and documentation can be found via the project’s GitHub page.
- ItemFarmer typology to understand differentiated climate change adaptation in Himalaya([London] : Macmillan Publishers Limited, part of Springer Nature, 2019) Shukla, Roopam; Agarwal, Ankit; Gornott, Christoph; Sachdeva, Kamna; Joshi, P.K.Smallholder farmers’ responses to the climate-induced agricultural changes are not uniform but rather diverse, as response adaptation strategies are embedded in the heterogonous agronomic, social, economic, and institutional conditions. There is an urgent need to understand the diversity within the farming households, identify the main drivers and understand its relationship with household adaptation strategies. Typology construction provides an efficient method to understand farmer diversity by delineating groups with common characteristics. In the present study, based in the Uttarakhand state of Indian Western Himalayas, five farmer types were identified on the basis of resource endowment and agriculture orientation characteristics. Factor analysis followed by sequential agglomerative hierarchial and K-means clustering was use to delineate farmer types. Examination of adaptation strategies across the identified farmer types revealed that mostly contrasting and type-specific bundle of strategies are adopted by farmers to ensure livelihood security. Our findings show that strategies that incurred high investment, such as infrastructural development, are limited to high resource-endowed farmers. In contrast, the low resourced farmers reported being progressively disengaging with farming as a livelihood option. Our results suggest that the proponents of effective adaptation policies in the Himalayan region need to be cognizant of the nuances within the farming communities to capture the diverse and multiple adaptation needs and constraints of the farming households. © 2019, The Author(s).
- ItemMedical ethics in the Anthropocene: how are €100 billion of German physicians' pension funds invested?(Amsterdam : Elsevier, 2019) Schulz, Christian M.; Ahrend, Klaus-Michael; Schneider, Gerhard; Hohendorf, Gerrit; Schellnhuber, Hans Joachim; Busse, Reinhard[No abstract available]