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search.filters.applied.f.access: openAccess × End date: 2024 × Start date: 2020 × DDC: 500 × Subject: Animals × WGL Institute: PIK ×

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    Modified wavelet analysis of ECoG-pattern as promising tool for detection of the blood–brain barrier leakage
    ([London] : Macmillan Publishers Limited, part of Springer Nature, 2021) Runnova, Anastasiya; Zhuravlev, Maksim; Ukolov, Rodion; Blokhina, Inna; Dubrovski, Alexander; Lezhnev, Nikita; Sitnikova, Evgeniya; Saranceva, Elena; Kiselev, Anton; Karavaev, Anatoly; Selskii, Anton; Semyachkina-Glushkovskaya, Oxana; Penzel, Thomas; Kurths, Jurgen
    A new approach for detection oscillatory patterns and estimation of their dynamics based by a modified CWT skeleton method is presented. The method opens up additional perspectives for the analysis of subtle changes in the oscillatory activity of complex nonstationary signals. The method was applied to analyze unique experimental signals obtained in usual conditions and after the non-invasive increase in the blood–brain barrier (BBB) permeability in 10 male Wistar rats. The results of the wavelet-analysis of electrocorticography (ECoG) recorded in a normal physiological state and after an increase in the BBB permeability of animals demonstrate significant changes between these states during wakefulness of animals and an essential smoothing of these differences during sleep. Sleep is closely related to the processes of observed changes in the BBB permeability.
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    Climatic windows for human migration out of Africa in the past 300,000 years
    ([London] : Nature Publishing Group UK, 2021) Beyer, Robert M.; Krapp, Mario; Eriksson, Anders; Manica, Andrea
    Whilst an African origin of modern humans is well established, the timings and routes of their expansions into Eurasia are the subject of heated debate, due to the scarcity of fossils and the lack of suitably old ancient DNA. Here, we use high-resolution palaeoclimate reconstructions to estimate how difficult it would have been for humans in terms of rainfall availability to leave the African continent in the past 300k years. We then combine these results with an anthropologically and ecologically motivated estimate of the minimum level of rainfall required by hunter-gatherers to survive, allowing us to reconstruct when, and along which geographic paths, expansions out of Africa would have been climatically feasible. The estimated timings and routes of potential contact with Eurasia are compatible with archaeological and genetic evidence of human expansions out of Africa, highlighting the key role of palaeoclimate variability for modern human dispersals.