Filters

2011 - 2019202020 - 20223

More filters

2020 - 202223
Reset filters

Settings

search.filters.applied.f.access: openAccess Ă— Publisher: Basel : MDPI AG Ă— WGL Institute: PIK Ă—

Search Results

Now showing 1 - 10 of 23
  • Thumbnail Image
    Item
    Photostimulation of extravasation of beta-amyloid through the model of blood-brain barrier
    (Basel : MDPI AG, 2020) Zinchenko, Ekaterina; Klimova, Maria; Mamedova, Aysel; Agranovich, Ilana; Blokhina, Inna; Antonova, Tatiana; Terskov, Andrey; Shirokov, Alexander; Navolokin, Nikita; Morgun, Andrey; Osipova, Elena; Boytsova, Elizaveta; Yu, Tingting; Zhu, Dan; Kurths, Juergen; Semyachkina-Glushkovskaya, Oxana
    Alzheimer’s disease (AD) is an incurable pathology associated with progressive decline in memory and cognition. Phototherapy might be a new promising and alternative strategy for the effective treatment of AD, and has been actively discussed over two decades. However, the mechanisms of therapeutic photostimulation (PS) effects on subjects with AD remain poorly understood. The goal of this study was to determine the mechanisms of therapeutic PS effects in beta-amyloid (Aβ)-injected mice. The neurological severity score and the new object recognition tests demonstrate that PS 9 J/cm2 attenuates the memory and neurological deficit in mice with AD. The immunohistochemical assay revealed a decrease in the level of Aβ in the brain and an increase of Aβ in the deep cervical lymph nodes obtained from mice with AD after PS. Using the in vitro model of the blood-brain barrier (BBB), we show a PS-mediated decrease in transendothelial resistance and in the expression of tight junction proteins as well an increase in the BBB permeability to Aβ. These findings suggest that a PS-mediated BBB opening and the activation of the lymphatic clearance of Aβ from the brain might be a crucial mechanism underlying therapeutic effects of PS in mice with AD. These pioneering data open new strategies in the development of non-pharmacological methods for therapy of AD and contribute to a better understanding of the PS effects on the central nervous system. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
  • Thumbnail Image
    Item
    Analysing Interlinked Frequency Dynamics of the Urban Acoustic Environment
    (Basel : MDPI AG, 2022) Haselhoff, Timo; Braun, Tobias; Hornberg, Jonas; Lawrence, Bryce T.; Ahmed, Salman; Gruehn, Dietwald; Moebus, Susanne
    As sustainable metropolitan regions require more densely built-up areas, a comprehensive understanding of the urban acoustic environment (AE) is needed. However, comprehensive datasets of the urban AE and well-established research methods for the AE are scarce. Datasets of audio recordings tend to be large and require a lot of storage space as well as computationally expensive analyses. Thus, knowledge about the long-term urban AE is limited. In recent years, however, these limitations have been steadily overcome, allowing a more comprehensive analysis of the urban AE. In this respect, the objective of this work is to contribute to a better understanding of the time-frequency domain of the urban AE, analysing automatic audio recordings from nine urban settings over ten months. We compute median power spectra as well as normalised spectrograms for all settings. Additionally, we demonstrate the use of frequency correlation matrices (FCMs) as a novel approach to access large audio datasets. Our results show site-dependent patterns in frequency dynamics. Normalised spectrograms reveal that frequency bins with low power hold relevant information and that the AE changes considerably over a year. We demonstrate that this information can be captured by using FCMs, which also unravel communities of interlinked frequency dynamics for all settings.
  • Thumbnail Image
    Item
    Interactive presentation of geo-spatial climate data in multi-display environments
    (Basel : MDPI AG, 2015) Eichner, C.; Nocke, T.; Schulz, H.-J.; Schumann, H.
  • Thumbnail Image
    Item
    Awareness, Experience, and Knowledge of Farming Households in Rural Bangladesh Regarding Mold Contamination of Food Crops: A Cross-Sectional Study
    (Basel : MDPI AG, 2021) Kyei, Nicholas N. A.; Waid, Jillian L; Ali, Nurshad; Gabrysch, Sabine
    Aside from specific environmental conditions, poor agricultural practices contribute to mold and thus the mycotoxin contamination of crops. This study investigated Bangladeshi farming households’ (i) awareness of and experience with mold contamination of food crops; (ii) knowledge and awareness of the timing, causes, and consequences of mold and mycotoxin contamination; and (iii) knowledge of the recommended agricultural practices for controlling and preventing mold contamination of food crops. A survey was conducted with 1280 households in rural areas of Habiganj district, Bangladesh. Basic descriptive statistics were calculated, and mixed-effects linear regression analyses were performed to examine associations between household characteristics and overall knowledge scores. The awareness of mold contamination of food crops was very high (99%; 95% CI: 98–100%) and a shared experience among households (85%; 95% CI: 80–88%). Yet, the majority (80%; 95% CI: 76–84%) demonstrated a low level of knowledge of the timing, causes, and preventive practices regarding mold contamination of crops. Knowledge scores were similar over demographic groups and better for households with more arable land. The findings suggest a generally insufficient knowledge of the conditions that favor mold contamination and the measures for preventing mold contamination of food crops. These findings underline the need for tailored interventions to promote good agricultural practices and reduce mold contamination of food crops.
  • Thumbnail Image
    Item
    Global and regional variability and change in terrestrial ecosystems net primary production and NDVI: A model-data comparison
    (Basel : MDPI AG, 2016) Rafique, R.; Zhao, F.; De Jong, R.; Zeng, N.; Asrar, G.R.
  • Thumbnail Image
    Item
    Effect of climate change on hydrology, sediment and nutrient losses in two lowland catchments in Poland
    (Basel : MDPI AG, 2017) Marcinkowski, P.; Piniewski, M.; Kardel, I.; Szcześniak, M.; Benestad, R.; Srinivasan, R.; Ignar, S.; Okruszko, T.
    Future climate change is projected to have significant impact on water resources availability and quality in many parts of the world. The objective of this paper is to assess the effect of projected climate change on water quantity and quality in two lowland catchments (the Upper Narew and the Barycz) in Poland in two future periods (near future: 2021-2050, and far future: 2071-2100). The hydrological model SWAT was driven by climate forcing data from an ensemble of nine bias-corrected General Circulation Models-Regional Climate Models (GCM-RCM) runs based on the Coordinated Downscaling Experiment-European Domain (EURO-CORDEX). Hydrological response to climate warming and wetter conditions (particularly in winter and spring) in both catchments includes: lower snowmelt, increased percolation and baseflow and higher runoff. Seasonal differences in the response between catchments can be explained by their properties (e.g., different thermal conditions and soil permeability). Projections suggest only moderate increases in sediment loss, occurring mainly in summer and winter. A sharper increase is projected in both catchments for TN losses, especially in the Barycz catchment characterized by a more intensive agriculture. The signal of change in annual TP losses is blurred by climate model uncertainty in the Barycz catchment, whereas a weak and uncertain increase is projected in the Upper Narew catchment.
  • Thumbnail Image
    Item
  • Thumbnail Image
    Item
    A semantic sensor web for environmental decision support applications
    (Basel : MDPI AG, 2011) Gray, A.J.G.; Sadler, J.; Kit, O.; Kyzirakos, K.; Karpathiotakis, M.; Calbimonte, J.-P.; Page, K.; Garćia-Castro, R.; Frazer, A.; Galpin, I.; Fernandes, A.A.A.; Paton, N.W.; Corcho, O.; Koubarakis, M.; de Roure, D.; Martinez, K.; Gómez-Pérez, A.
    Sensing devices are increasingly being deployed to monitor the physical world around us. One class of application for which sensor data is pertinent is environmental decision support systems, e.g., flood emergency response. For these applications, the sensor readings need to be put in context by integrating them with other sources of data about the surrounding environment. Traditional systems for predicting and detecting floods rely on methods that need significant human resources. In this paper we describe a semantic sensor web architecture for integrating multiple heterogeneous datasets, including live and historic sensor data, databases, and map layers. The architecture provides mechanisms for discovering datasets, defining integrated views over them, continuously receiving data in real-time, and visualising on screen and interacting with the data. Our approach makes extensive use of web service standards for querying and accessing data, and semantic technologies to discover and integrate datasets. We demonstrate the use of our semantic sensor web architecture in the context of a flood response planning web application that uses data from sensor networks monitoring the sea-state around the coast of England.
  • Thumbnail Image
    Item
    Climate change, agriculture, and economic development in Ethiopia
    (Basel : MDPI AG, 2018) Yalew, A.W.; Hirte, G.; Lotze-Campen, H.; Tscharaktschiew, S.
    Quantifying the economic effects of climate change is a crucial step for planning adaptation in developing countries. This study assesses the economy-wide and regional effects of climate change-induced productivity and labor supply shocks in Ethiopian agriculture. We pursue a structural approach that blends biophysical and economic models. We consider different crop yield projections and add a regionalization to the country-wide CGE results. The study shows, in the worst case scenario, the effects on country-wide GDP may add up to -8%. The effects on regional value-added GDP are uneven and range from -10% to +2.5%. However, plausible cost-free exogenous structural change scenarios in labor skills and marketing margins may offset about 20-30% of these general equilibrium effects. As such, the ongoing structural transformation in the country may underpin the resilience of the economy to climate change. This can be regarded as a co-benefit of structural change in the country. Nevertheless, given the role of the sector in the current economic structure and the potency of the projected biophysical impacts, adaptation in agriculture is imperative. Otherwise, climate change may make rural livelihoods unpredictable and strain the country's economic progress.
  • Thumbnail Image
    Item
    Evaluation of ecological criteria of biofuel certification in Germany
    (Basel : MDPI AG, 2016) Selbmann, K.; Pforte, L.