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Catalytic β-Bromohydroxylation of Natural Terpenes: Useful Intermediates for the Synthesis of Terpenic Epoxides

2018, Oubaassine, Saadia, Köckritz, Angela, Eckelt, Reinhard, Martin, Andreas, Ait Ali, Mustapha, El Firdoussi, Larbi

In a one-step procedure, various ß-bromoalcohols were synthesized from natural terpenes in good to excellent yields. Using different catalysts, the reaction was carried out at room temperature, with H 2 O as nucleophile and N-bromosuccinimide as a bromine source under mild reaction conditions. The synthesized ß-bromoalcohols were subsequently converted in situ to the corresponding epoxides in good yields. © 2019 Saadia Oubaassine et al.