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Author: Avitabile, D. × Subject: human × Subject: metabolism ×

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    Growth induction and low-oxygen apoptosis inhibition of human CD34 + progenitors in collagen gels
    (New York, NY : Hindawi, 2013) Avitabile, D.; Salchert, K.; Werner, C.; Capogrossi, M.C.; Pesce, M.
    Various reports have indicated low survival of injected progenitors into unfavorable environments such as the ischemic myocardium or lower limb tissues. This represents a major bottleneck in stem-cell-based cardiovascular regenerative medicine. Strategies to enhance survival of these cells in recipient tissues have been therefore sought to improve stem cell survival and ensure long-term engraftment. In the present contribution, we show that embedding human cord blood-derived CD34+ cells into a collagen I-based hydrogel containing cytokines is a suitable strategy to promote stem cell proliferation and protect these cells from anoxia-induced apoptosis.