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- ItemEfficient palladium-catalyzed synthesis of 2-aryl propionic acids(Basel : MDPI, 2020) Neumann, Helfried; Sergeev, Alexey G.; Spannenberg, Anke; Beller, MatthiasA flexible two-step, one-pot procedure was developed to synthesize 2-aryl propionic acids including the anti-inflammatory drugs naproxen and flurbiprofen. Optimal results were obtained in the presence of the novel ligand neoisopinocampheyldiphenylphosphine (NISPCPP) (9) which enabled the efficient sequential palladium-catalyzed Heck coupling of aryl bromides with ethylene and hydroxycarbonylation of the resulting styrenes to 2-aryl propionic acids. This cascade transformation leads with high regioselectivity to the desired products in good yields and avoids the need for additional purification steps. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
- ItemFacile synthesis of iron-titanate nanocomposite as a sustainable material for selective amination of substitued nitro-arenes(Basel : MDPI, 2020) Sohail, Manzar; Tahir, Nimra; Rubab, Anosha; Beller, Matthias; Sharif, MuhammadThe fabrication of durable and low-cost nanostructured materials remains important in chemical, biologic and medicinal applications. Particularly, iron-based nanomaterials are of central importance due to the ‘noble’ features of iron such as its high abundance, low cost and non-toxicity. Herein we report a simple sol–gel method for the synthesis of novel iron–titanium nanocomposite-based material (Fe9TiO15@TiO2). In order to prepare this material, we made a polymeric gel using ferrocene, titanium isopropoxide and THF precursors. The calcination of this gel in air at 500◦C produced Fe-Ti bimetallic nanoparticles-based composite and nano-TiO2 as support. Noteworthy, our methodology provides an excellent control over composition, size and shape of the resulting nanoparticles. The resulted Fe-based material provides a sustainable catalyst for selective synthesis of anilines, which are key intermediates for the synthesis of several chemicals, dyes and materials, via reduction of structurally diverse and functionalized nitroarenes. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.