Filters

2017 - 20195

More filters

2020 - 20235
Reset filters

Settings

Author: Beller, Matthias × End date: 2019 × DDC: 540 × Type: article ×

Search Results

Now showing 1 - 5 of 5
  • Thumbnail Image
    Item
    Manganese Catalyzed Asymmetric Transfer Hydrogenation of Ketones Using Chiral Oxamide Ligands
    (Stuttgart [u.a.] : Thieme, 2019) Schneekönig, Jacob; Junge, Kathrin; Beller, Matthias
    The asymmetric transfer hydrogenation of ketones using isopropyl alcohol (IPA) as hydrogen donor in the presence of novel manganese catalysts is explored. The selective and active systems are easily generated in situ from [MnBr(CO)5] and inexpensive C 2-symmeric bisoxalamide ligands. Under the optimized reaction conditions, the Mn-derived catalyst gave higher enantioselectivity compared with the related ruthenium catalyst.
  • Thumbnail Image
    Item
    Isoquinolinamine FX-9 Exhibits Anti-Mitotic Activity in Human and Canine Prostate Carcinoma Cell Lines
    (Basel : Molecular Diversity Preservation International, 2019) Schille, Jan Torben; Nolte, Ingo; Packeiser, Eva-Maria; Wiesner, Laura; Hein, Jens Ingo; Weiner, Franziska; Wu, Xiao-Feng; Beller, Matthias; Junghanss, Christian; Escobar, Hugo Murua
    Current therapies are insufficient for metastatic prostate cancer (PCa) in men and dogs. As human castrate-resistant PCa shares several characteristics with the canine disease, comparative evaluation of novel therapeutic agents is of considerable value for both species. Novel isoquinolinamine FX-9 exhibits antiproliferative activity in acute lymphoblastic leukemia cell lines but has not been tested yet on any solid neoplasia type. In this study, FX-9's mediated effects were characterized on two human (PC-3, LNCaP) and two canine (CT1258, 0846) PCa cell lines, as well as benign solid tissue cells. FX-9 significantly inhibited cell viability and induced apoptosis with concentrations in the low micromolar range. Mediated effects were highly comparable between the PCa cell lines of both species, but less pronounced on non-malignant chondrocytes and fibroblasts. Interestingly, FX-9 exposure also leads to the formation and survival of enlarged multinucleated cells through mitotic slippage. Based on the results, FX-9 acts as an anti-mitotic agent with reduced cytotoxic activity in benign cells. The characterization of FX-9-induced effects on PCa cells provides a basis for in vivo studies with the potential of valuable transferable findings to the benefit of men and dogs. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
  • Thumbnail Image
    Item
    Monodisperse nickel-nanoparticles for stereo- and chemoselective hydrogenation of alkynes to alkenes
    (Amsterdam [u.a.] : Elsevier, 2019) Murugesan, Kathiravan; Alshammari, Ahmad S.; Sohail, Manzar; Beller, Matthias; Jagadeesh, Rajenahally V.
    Here, we report the use of monosaccharides for the preparation of novel nickel nanoparticles (NP), which constitute selective hydrogenation catalysts. For example, immobilization of fructose and Ni(OAc)2 on silica and subsequent pyrolysis under inert atmosphere produced graphitic shells encapsulated Ni-NP with uniform size and distribution. Interestingly, fructose acts as structure controlling compound to generate specific graphitic layers and the formation of monodisperse NP. The resulting stable and reusable catalysts allow for stereo- and chemoselective semihydrogenation of functionalized and structurally diverse alkynes in high yields and selectivity. © 2019 The Author(s)
  • Thumbnail Image
    Item
    Tetra­carbon­yl[4,4-dimethyl-2-(pyridin-2-yl)-2-oxazoline-κ2N,N′]molybdenum(0)
    (Chester : IUCr, 2019) Steinlechner, Christoph; Spannenberg, Anke; Junge, Henrik; Beller, Matthias
    In the title compound, [Mo(C10H12N2O)(CO)4], the molybdenum(0) center is surrounded by a bidentate di­imine [4,4-dimethyl-2-(pyridin-2-yl)-2-oxazoline] and four carbonyl ligands in a distorted octa­hedral coordination geometry. The di­imine ligand coordinates via the two nitro­gen atoms.
  • Thumbnail Image
    Item
    Earth-abundant photocatalytic systems for the visible-light-driven reduction of CO2 to CO
    (Cambridge : RSC, 2017) Rosas-Hernández, Alonso; Steinlechner, Christoph; Junge, Henrik; Beller, Matthias
    Herein, we report a highly selective photocatalytic system, based on an in situ copper photosensitizer and an iron catalyst, for the reduction of CO2 to CO. Turnover numbers (TON) up to 487 (5 h) with selectivities up to 99% and ΦCO = 13.3% were observed. Stern-Volmer analysis allowed us to establish a reductive quenching mechanism between the Cu PS and electron donor.