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Author: Beller, Matthias × Subject: hydrogen ×

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    Manganese-catalyzed selective C–H activation and deuteration by means of a catalytic transient directing group strategy
    (London : Royal Society of Chemistry (RSC), 2021) Kopf, Sara; Neumann, Helfried; Beller, Matthias
    A novel manganese-catalyzed C-H activation methodology for selective hydrogen isotope exchange of benzaldehydes is presented. Using D2O as a cheap and convenient source of deuterium, the reaction proceeds with excellent functional group tolerance. Highortho-selectivity is achieved in the presence of catalytic amounts of specific amines, whichin situform a transient directing group. © The Royal Society of Chemistry 2021.
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    Homogeneous and heterogeneous catalytic reduction of amides and related compounds using molecular hydrogen
    ([London] : Nature Publishing Group UK, 2020) Cabrero-Antonino, Jose R.; Adam, Rosa; Papa, Veronica; Beller, Matthias
    Catalytic hydrogenation of amides is of great interest for chemists working in organic synthesis, as the resulting amines are widely featured in natural products, drugs, agrochemicals, dyes, etc. Compared to traditional reduction of amides using (over)stoichiometric reductants, the direct hydrogenation of amides using molecular hydrogen represents a greener approach. Furthermore, amide hydrogenation is a highly versatile transformation, since not only higher amines (obtained by C–O cleavage), but also lower amines and alcohols, or amino alcohols (obtained by C–N cleavage) can be selectively accessed by fine tuning of reaction conditions. This review describes the most recent advances in the area of amide hydrogenation using H2 exclusively and molecularly defined homogeneous as well as nano-structured heterogeneous catalysts, with a special focus on catalyst development and synthetic applications.