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- ItemEffectiveness of myAirCoach: A mHealth Self-Management System in Asthma(Amsterdam [u.a.] : Elsevier, 2020) Khusial, Rishi J.; Honkoop, Persijn J.; Usmani, Omar; Soares, Marcia; Simpson, Andrew; Biddiscombe, Martyn; Meah, Sally; Bonini, Matteo; Lalas, Antonios; Polychronidou, Eleftheria; Koopmans, Julia G.; Moustakas, Konstantinos; Snoeck-Stroband, Jiska B.; Ortmann, Steffen; Votis, Konstantinos; Tzovaras, Dimitrios; Chung, Kian Fan; Fowler, Stephen; Sont, Jacob K.Background: Self-management programs have beneficial effects on asthma control, but their implementation in clinical practice is poor. Mobile health (mHealth) could play an important role in enhancing self-management. Objective: To assess the clinical effectiveness and technology acceptance of myAirCoach-supported self-management on top of usual care in patients with asthma using inhalation medication. Methods: Patients were recruited in 2 separate studies. The myAirCoach system consisted of an inhaler adapter, an indoor air-quality monitor, a physical activity tracker, a portable spirometer, a fraction exhaled nitric oxide device, and an app. The primary outcome was asthma control; secondary outcomes were exacerbations, quality of life, and technology acceptance. In study 1, 30 participants were randomized to either usual care or myAirCoach support for 3 to 6 months; in study 2, 12 participants were provided with the myAirCoach system in a 3-month before-after study. Results: In study 1, asthma control improved in the intervention group compared with controls (Asthma Control Questionnaire difference, 0.70; P = .006). A total of 6 exacerbations occurred in the intervention group compared with 12 in the control group (hazard ratio, 0.31; P = .06). Asthma-related quality of life improved (mini Asthma-related Quality of Life Questionnaire difference, 0.53; P = .04), but forced expiratory volume in 1 second was unchanged. In study 2, asthma control improved by 0.86 compared with baseline (P = .007) and quality of life by 0.16 (P = .64). Participants reported positive attitudes toward the system. Discussion: Using the myAirCoach support system improves asthma control and quality of life, with a reduction in severe asthma exacerbations. Well-validated mHealth technologies should therefore be further studied. © 2020 The Authors