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Author: De Laporte, Laura × Subject: Medical applications ×

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    Predicting the orientation of magnetic microgel rods for soft anisotropic biomimetic hydrogels
    (Cambridge : RSC Publ., 2020) Rose, Jonas C.; Fölster, Maaike; Kivilip, Lukas; Gerardo-Nava, Jose L.; Jaekel, Esther E.; Gehlen, David B.; Rohlfs, Wilko; De Laporte, Laura
    Living multicellular organisms comprise a high degree of soft anisotropic tissues but the development of controlled artificial assembly processes to mimic them remains challenging. Therefore, injectable, polymeric, magneto-responsive microgel rods are fabricated to orient within a low magnetic field. The incorporated superparamagnetic nanoparticles induce local dipole moments, resulting in a total magnetic torque that endows microgels with different structural, mechanical, and biochemical properties. In this report, a predictive macroscopic model based on an ellipsoidal element dispersed in a Newtonian fluid is adjusted using experimental data, which enables the prediction of the orientation rate and the required magnetic field strength for various microgel design parameters and fluid viscosities. The ordered microgels are fixed by crosslinking of a surrounding hydrogel, and can be employed for a wide variety of applications where anisotropic composite hydrogels play a crucial role; for instance as adaptive materials or in biomedical applications, wherein the model predictions can reduce animal experiments. © 2019 The Royal Society of Chemistry.
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    Microfluidic fabrication of polyethylene glycol microgel capsules with tailored properties for the delivery of biomolecules
    (Cambridge : RSC, 2017) Guerzoni, Luis P. B.; Bohl, Jan; Jans, Alexander; Rose, Jonas C.; Koehler, Jens; Kuehne, Alexander J. C.; De Laporte, Laura
    Microfluidic encapsulation platforms have great potential not only in pharmaceutical applications but also in the consumer products industry. Droplet-based microfluidics is increasingly used for the production of monodisperse polymer microcapsules for biomedical applications. In this work, a microfluidic technique is developed for the fabrication of monodisperse double emulsion droplets, where the shell is crosslinked into microgel capsules. A six-armed acrylated star-shaped poly(ethylene oxide-stat-propylene oxide) pre-polymer is used to form the microgel shell after a photo-initiated crosslinking reaction. The synthesized microgel capsules are hollow, enabling direct encapsulation of large amounts of multiple biomolecules with the inner aqueous phase completely engulfed inside the double emulsion droplets. The shell thickness and overall microgel sizes can be controlled via the flow rates. The morphology and size of the shells are characterized by cryo-SEM. The encapsulation and retention of 10 kDa FITC-dextran and its microgel degradation mediated release are monitored by fluorescence microscopy. © 2017 The Royal Society of Chemistry.