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Author: Dietzek, Benjamin × Author: McFarland, Sherri A. × End date: 2021 × Start date: 2020 × Publisher: Weinheim : Wiley-VCH × Subject: ruthenium ×

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    It Takes Three to Tango - the length of the oligothiophene determines the nature of the long-lived excited state and the resulting photocytotoxicity of a Ru(II) photodrug
    (Weinheim : Wiley-VCH, 2021) Chettri, Avinash; Roque, John A.; Schneider, Kilian R.A.; Cole, Houston D.; Cameron, Colin G.; McFarland, Sherri A.; Dietzek, Benjamin
    TLD1433 is the first Ru(II) complex to be tested as a photodynamic therapy agent in a clinical trial. In this contribution we study TLD1433 in the context of structurally-related Ru(II)-imidozo[4,5-f][1,10]phenanthroline (ip) complexes appended with thiophene rings to decipher the unique photophysical properties which are associated with increasing oligothiophene chain length. Substitution of the ip ligand with ter- or quaterthiophene changes the nature of the long-lived triplet state from metal-to-ligand charge-transfer to 3ππ* character. The addition of the third thiophene thus presents a critical juncture which not only determines the photophysics of the complex but most importantly its capacity for 1O2 generation and hence the potential of the complex to be used as a photocytotoxic agent.