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Author: Gao, Peng × End date: 2024 × Start date: 2020 × DDC: 500 × Type: article × WGL Institute: IPF ×

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    Corrigendum to "A Versatile Surface Bioengineering Strategy Based on Mussel-Inspired and Bioclickable Peptide Mimic"
    ([Beijing] : China Association for Science and Technology, 2021) Xiao, Yu; Wang, Wenxuan; Tian, Xiaohua; Tan, Xing; Yang, Tong; Gao, Peng; Xiong, Kaiqing; Tu, Qiufen; Wang, Miao; Maitz, Manfred F.; Huang, Nan; Pan, Guoqing; Yang, Zhilu
    [This corrects the article DOI: 10.34133/2020/7236946.].
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    Endothelium-Mimicking Multifunctional Coating Modified Cardiovascular Stents via a Stepwise Metal-Catechol-(Amine) Surface Engineering Strategy
    (Washington, DC [u.a.] : American Association for the Advancement of Science, 2020) Yang, Ying; Gao, Peng; Wang, Juan; Tu, Qiufen; Bai, Long; Xiong, Kaiqin; Qiu, Hua; Zhao, Xin; Maitz, Manfred F.; Wang, Huaiyu; Li, Xiangyang; Zhao, Qiang; Xiao, Yin; Huang, Nan; Yang, Zhilu
    Stenting is currently the major therapeutic treatment for cardiovascular diseases. However, the nonbiogenic metal stents are inclined to trigger a cascade of cellular and molecular events including inflammatory response, thrombogenic reactions, smooth muscle cell hyperproliferation accompanied by the delayed arterial healing, and poor reendothelialization, thus leading to restenosis along with late stent thrombosis. To address prevalence critical problems, we present an endothelium-mimicking coating capable of rapid regeneration of a competently functioning new endothelial layer on stents through a stepwise metal (copper)-catechol-(amine) (MCA) surface chemistry strategy, leading to combinatorial endothelium-like functions with glutathione peroxidase-like catalytic activity and surface heparinization. Apart from the stable nitric oxide (NO) generating rate at the physiological level (2:2 × 10a'10 mol/cm2/min lasting for 60 days), this proposed strategy could also generate abundant amine groups for allowing a high heparin conjugation efficacy up to ∼1 μg/cm2, which is considerably higher than most of the conventional heparinized surfaces. The resultant coating could create an ideal microenvironment for bringing in enhanced antithrombogenicity, anti-inflammation, anti-proliferation of smooth muscle cells, re-endothelialization by regulating relevant gene expressions, hence preventing restenosis in vivo. We envision that the stepwise MCA coating strategy would facilitate the surface endothelium-mimicking engineering of vascular stents and be therefore helpful in the clinic to reduce complications associated with stenosis. © 2020 American Association for the Advancement of Science. All rights reserved.
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    A Versatile Surface Bioengineering Strategy Based on Mussel-Inspired and Bioclickable Peptide Mimic
    ([Beijing] : China Association for Science and Technology, 2020) Xiao, Yu; Wang, Wenxuan; Tian, Xiaohua; Tan, Xing; Yang, Tong; Gao, Peng; Xiong, Kaiqing; Tu, Qiufen; Wang, Miao; Maitz, Manfred F.; Huang, Nan; Pan, Guoqing; Yang, Zhilu
    In this work, we present a versatile surface engineering strategy by the combination of mussel adhesive peptide mimicking and bioorthogonal click chemistry. The main idea reflected in this work derived from a novel mussel-inspired peptide mimic with a bioclickable azide group (i.e., DOPA4-azide). Similar to the adhesion mechanism of the mussel foot protein (i.e., covalent/noncovalent comediated surface adhesion), the bioinspired and bioclickable peptide mimic DOPA4-azide enables stable binding on a broad range of materials, such as metallic, inorganic, and organic polymer substrates. In addition to the material universality, the azide residues of DOPA4-azide are also capable of a specific conjugation of dibenzylcyclooctyne- (DBCO-) modified bioactive ligands through bioorthogonal click reaction in a second step. To demonstrate the applicability of this strategy for diversified biofunctionalization, we bioorthogonally conjugated several typical bioactive molecules with DBCO functionalization on different substrates to fabricate functional surfaces which fulfil essential requirements of biomedically used implants. For instance, antibiofouling, antibacterial, and antithrombogenic properties could be easily applied to the relevant biomaterial surfaces, by grafting antifouling polymer, antibacterial peptide, and NO-generating catalyst, respectively. Overall, the novel surface bioengineering strategy has shown broad applicability for both the types of substrate materials and the expected biofunctionalities. Conceivably, the “clean” molecular modification of bioorthogonal chemistry and the universality of mussel-inspired surface adhesion may synergically provide a versatile surface bioengineering strategy for a wide range of biomedical materials.