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Author: Grobert, Nicole × Version: publishedVersion ×

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    Targeted T1 Magnetic Resonance Imaging Contrast Enhancement with Extraordinarily Small CoFe2O4 Nanoparticles
    (Washington, DC : American Chemical Society, 2019) Piché, Dominique; Tavernaro, Isabella; Fleddermann, Jana; Lozano, Juan G.; Varambhia, Aakash; Maguire, Mahon L.; Koch, Marcus; Ukai, Tomofumi; Hernández Rodríguez, Armando J.; Jones, Lewys; Dillon, Frank; Reyes Molina, Israel; Mitzutani, Mai; González Dalmau, Evelio R.; Maekawa, Toru; Nellist, Peter D.; Kraegeloh, Annette; Grobert, Nicole
    Extraordinarily small (2.4 nm) cobalt ferrite nanoparticles (ESCIoNs) were synthesized by a one-pot thermal decomposition approach to study their potential as magnetic resonance imaging (MRI) contrast agents. Fine size control was achieved using oleylamine alone, and annular dark-field scanning transmission electron microscopy revealed highly crystalline cubic spinel particles with atomic resolution. Ligand exchange with dimercaptosuccinic acid rendered the particles stable in physiological conditions with a hydrodynamic diameter of 12 nm. The particles displayed superparamagnetic properties and a low r2/r1 ratio suitable for a T1 contrast agent. The particles were functionalized with bile acid, which improved biocompatibility by significant reduction of reactive oxygen species generation and is a first step toward liver-targeted T1 MRI. Our study demonstrates the potential of ESCIoNs as T1 MRI contrast agents.
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    Facile, fast, and inexpensive synthesis of monodisperse amorphous Nickel-Phosphide nanoparticles of predefined size
    (Cambridge : Royal Society of Chemistry, 2011) Arzt, Eduard; Moh, Karsten; Cavelius, Christian; Mandel, Karl; Dillon, Frank; Koos, Antal A.; Aslam, Zabeada; Jurkschat, Kerstin; Cullen, Frank; Crossley, Alison; Bishop, Hugh; Grobert, Nicole
    Monodisperse, size-controlled Ni–P nanoparticles were synthesised in a single step process using triphenyl-phosphane (TPP), oleylamine (OA), and Ni(II)acetyl-acetonate. The nanoparticles were amorphous, contained 30 at% P and their size was controlled between 7–21 nm simply by varying the amount of TPP. They are catalytically active for tailored carbon nanotube growth.