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Author: Huang, Jing × Type: Text ×

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    Vibrational Spectroscopic Investigation of Blood Plasma and Serum by Drop Coating Deposition for Clinical Application
    (Basel : Molecular Diversity Preservation International (MDPI), 2021) Huang, Jing; Ali, Nairveen; Quansah, Elsie; Guo, Shuxia; Noutsias, Michel; Meyer-Zedler, Tobias; Bocklitz, Thomas; Popp, Jürgen; Neugebauer, Ute; Ramoji, Anuradha
    In recent decades, vibrational spectroscopic methods such as Raman and FT-IR spectroscopy are widely applied to investigate plasma and serum samples. These methods are combined with drop coating deposition techniques to pre-concentrate the biomolecules in the dried droplet to improve the detected vibrational signal. However, most often encountered challenge is the inhomogeneous redistribution of biomolecules due to the coffee-ring effect. In this study, the variation in biomolecule distribution within the dried-sample droplet has been investigated using Raman and FT-IR spectroscopy and fluorescence lifetime imaging method. The plasma-sample from healthy donors were investigated to show the spectral differences between the inner and outer-ring region of the dried-sample droplet. Further, the preferred location of deposition of the most abundant protein albumin in the blood during the drying process of the plasma has been illustrated by using deuterated albumin. Subsequently, two patients with different cardiac-related diseases were investigated exemplarily to illustrate the variation in the pattern of plasma and serum biomolecule distribution during the drying process and its impact on patient-stratification. The study shows that a uniform sampling position of the droplet, both at the inner and the outer ring, is necessary for thorough clinical characterization of the patient’s plasma and serum sample using vibrational spectroscopy.
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    Observational Signatures of Tearing Instability in the Current Sheet of a Solar Flare
    (London : Institute of Physics Publ., 2022) Lu, Lei; Feng, Li; Warmuth, Alexander; Veronig, Astrid M.; Huang, Jing; Liu, Siming; Gan, Weiqun; Ning, Zongjun; Ying, Beili; Gao, Guannan
    Magnetic reconnection is a fundamental physical process converting magnetic energy into not only plasma energy but also particle energy in various astrophysical phenomena. In this Letter, we show a unique data set of a solar flare where various plasmoids were formed by a continually stretched current sheet. Extreme ultraviolet images captured reconnection inflows, outflows, and particularly the recurring plasma blobs (plasmoids). X-ray images reveal nonthermal emission sources at the lower end of the current sheet, presumably as large plasmoids with a sufficiently amount of energetic electrons trapped in them. In the radio domain, an upward, slowly drifting pulsation structure, followed by a rare pair of oppositely drifting structures, was observed. These structures are supposed to map the evolution of the primary and the secondary plasmoids formed in the current sheet. Our results on plasmoids at different locations and scales shed important light on the dynamics, plasma heating, particle acceleration, and transport processes in the turbulent current sheet and provide observational evidence for the cascading magnetic reconnection process.