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Author: Junge, Kathrin × DDC: 540 × Type: Text × Version: publishedVersion × Publisher: Weinheim : Wiley-VCH × Subject: hydrogenation × WGL Institute: LIKAT ×

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    A General Regioselective Synthesis of Alcohols by Cobalt-Catalyzed Hydrogenation of Epoxides
    (Weinheim : Wiley-VCH, 2020) Liu, Weiping; Leischner, Thomas; Li, Wu; Junge, Kathrin; Beller, Matthias
    A straightforward methodology for the synthesis of anti-Markovnikov-type alcohols is presented. By using a specific cobalt triphos complex in the presence of Zn(OTf)2 as an additive, the hydrogenation of epoxides proceeds with high yields and selectivities. The described protocol shows a broad substrate scope, including multi-substituted internal and terminal epoxides, as well as a good functional-group tolerance. Various natural-product derivatives, including steroids, terpenoids, and sesquiterpenoids, gave access to the corresponding alcohols in moderate-to-excellent yields. © 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
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    Non-Pincer-Type Manganese Complexes as Efficient Catalysts for the Hydrogenation of Esters
    (Weinheim : Wiley-VCH, 2017-4-21) van Putten, Robbert; Uslamin, Evgeny A.; Garbe, Marcel; Liu, Chong; Gonzalez-de-Castro, Angela; Lutz, Martin; Junge, Kathrin; Hensen, Emiel J. M.; Beller, Matthias; Lefort, Laurent; Pidko, Evgeny A.
    Catalytic hydrogenation of carboxylic acid esters is essential for the green production of pharmaceuticals, fragrances, and fine chemicals. Herein, we report the efficient hydrogenation of esters with manganese catalysts based on simple bidentate aminophosphine ligands. Monoligated Mn PN complexes are particularly active for the conversion of esters into the corresponding alcohols at Mn concentrations as low as 0.2 mol % in the presence of sub-stoichiometric amounts of KOtBu base.