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Author: Keskin, Sercan ×

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    A Highly Active Cobalt Catalyst for the General and Selective Hydrogenation of Aromatic Heterocycles
    (Weinheim : Wiley-VCH, 2023) Bauer, Christof; Müller, Felix; Keskin, Sercan; Zobel, Mirijam; Kempe, Rhett
    Nanostructured earth abundant metal catalysts that mediate important chemical reactions with high efficiency and selectivity are of great interest. This study introduces a synthesis protocol for nanostructured earth abundant metal catalysts. Three components, an inexpensive metal precursor, an easy to synthesize N/C precursor, and a porous support material undergo pyrolysis to give the catalyst material in a simple, single synthesis step. By applying this catalyst synthesis, a highly active cobalt catalyst for the general and selective hydrogenation of aromatic heterocycles could be generated. The reaction is important with regard to organic synthesis and hydrogen storage. The mild reaction conditions observed for quinolines permit the selective hydrogenation of numerous classes of N-, O- and S-heterocyclic compounds such as: quinoxalines, pyridines, pyrroles, indoles, isoquinoline, aciridine amine, phenanthroline, benzofuranes, and benzothiophenes.
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    Graphene Enclosure of Chemically Fixed Mammalian Cells for Liquid-Phase Electron Microscopy
    (Cambridge, MA : JoVE, 2020) Blach, Patricia; Keskin, Sercan; de Jonge, Niels
    A protocol is described for investigating the human epidermal growth factor receptor 2 (HER2) in the intact plasma membrane of breast cancer cells using scanning transmission electron microscopy (STEM). Cells of the mammalian breast cancer cell line SKBR3 were grown on silicon microchips with silicon nitride (SiN) windows. Cells were chemically fixed, and HER2 proteins were labeled with quantum dot nanoparticles (QDs), using a two-step biotin-streptavidin binding protocol. The cells were coated with multilayer graphene to maintain a hydrated state, and to protect them from electron beam damage during STEM. To examine the stability of the samples under electron beam irradiation, a dose series experiment was performed. Graphene-coated and non-coated samples were compared. Beam induced damage, in the form of bright artifacts, appeared for some non-coated samples at increased electron dose D, while no artifacts appeared on coated samples.
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    Ultrafast dissolution and creation of bonds in IrTe2 induced by photodoping
    (Washington, DC : American Association for the Advancement of Science, 2018) Ideta, Shin-ichiro; Zhang, Dongfang; Dijkstra, Arend G; Artyukhin, Sergey; Keskin, Sercan; Cingolani, Roberto; Shimojima, Takahiro; Ishizaka, Kyoko; Ishii, Hiroyuki; Kudo, Kazutaka; Nohara, Minoru; Miller, R.J. Dwayne
    The observation and control of interweaving spin, charge, orbital, and structural degrees of freedom in materials on ultrafast time scales reveal exotic quantum phenomena and enable new active forms of nanotechnology. Bond- ing is the prime example of the relation between electronic and nuclear degrees of freedom. We report direct evidence illustrating that photoexcitation can be used for ultrafast control of the breaking and recovery of bonds in solids on unprecedented time scales, near the limit for nuclear motions. We describe experimental and theoretical studies of IrTe2 using femtosecond electron diffraction and density functional theory to investigate bonding instability. Ir-Ir dimerization shows an unexpected fast dissociation and recovery due to the filling of the antibonding dxy orbital. Bond length changes of 20% in IrTe2 are achieved by effectively addressing the bonds directly through this relaxation process. These results could pave the way to ultrafast switching between metastable structures by photoinduced manipulation of the relative degree of bonding in this manner.