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Author: Kiefer, R. × End date: 2024 ×

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    Cycle dependence of a quasi-biennial variability in the solar interior
    (Oxford : Oxford Univ. Press, 2022) Mehta, T.; Jain, K.; Tripathy, S.C.; Kiefer, R.; Kolotkov, D.; Broomhall, A.-M.
    We investigated the solar cycle dependence on the presence and periodicity of the Quasi-Biennial Oscillation (QBO). Using helioseismic techniques, we used solar oscillation frequencies from the Global Oscillations Network Group (GONG), Michelson Doppler Imager (MDI), and Helioseismic and Magnetic Imager (HMI) in the intermediate-degree range to investigate the frequency shifts over Cycles 23 and 24. We also examined two solar activity proxies, the F10.7 index and the Mg ii index, for the last four solar cycles to study the associated QBO. The analyses were performed using Empirical Mode Decomposition (EMD) and the Fast Fourier Transform (FFT). We found that the EMD analysis method is susceptible to detecting statistically significant Intrinsic Mode Functions (IMFs) with periodicities that are overtones of the length of the data set under examination. Statistically significant periodicities, which were not due to overtones, were detected in the QBO range. We see a reduced presence of the QBO in Cycle 24 compared to Cycle 23. The presence of the QBO was not sensitive to the depth to which the p-mode travelled, nor the average frequency of the p-mode. The analysis further suggested that the magnetic field responsible for producing the QBO in frequency shifts of p-modes is anchored above approximately 0.95 R⊙.
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    Targeted delivery of functionalized PLGA nanoparticles to macrophages by complexation with the yeast Saccharomyces cerevisiae
    (Chichester : John Wiley and Sons Ltd, 2020) Kiefer, R.; Jurisic, M.; Dahlem, C.; Koch, M.; Schmitt, M.J.; Kiemer, A.K.; Schneider, M.; Breinig, F.
    Nanoparticles (NPs) are able to deliver a variety of substances into eukaryotic cells. However, their usage is often hampered by a lack of specificity, leading to the undesired uptake of NPs by virtually all cell types. In contrast to this, yeast is known to be specifically taken up into immune cells after entering the body. Therefore, we investigated the interaction of biodegradable surface-modified poly(lactic-co-glycolic acid) (PLGA) particles with yeast cells to overcome the unspecificity of the particulate carriers. Cells of different Saccharomyces cerevisiae strains were characterized regarding their interaction with PLGA-NPs under isotonic and hypotonic conditions. The particles were shown to efficiently interact with yeast cells leading to stable NP/yeast-complexes allowing to associate or even internalize compounds. Notably, applying those complexes to a coculture model of HeLa cells and macrophages, the macrophages were specifically targeted. This novel nano-in-micro carrier system suggests itself as a promising tool for the delivery of biologically active agents into phagocytic cells combining specificity and efficiency.