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- ItemKey Role of Reactive Oxygen Species (ROS) in Indirubin Derivative-Induced Cell Death in Cutaneous T-Cell Lymphoma Cells(Basel : Molecular Diversity Preservation International, 2019) Soltan, Marwa Y.; Sumarni, Uly; Assaf, Chalid; Langer, Peter; Reidel, Ulrich; Eberle, JürgenCutaneous T-cell lymphoma (CTCL) may develop a highly malignant phenotype in its late phase, and patients may profit from innovative therapies. The plant extract indirubin and its chemical derivatives represent new and promising antitumor strategies. This first report on the effects of an indirubin derivative in CTCL cells shows a strong decrease of cell proliferation and cell viability as well as an induction of apoptosis, suggesting indirubin derivatives for therapy of CTCL. As concerning the mode of activity, the indirubin derivative DKP-071 activated the extrinsic apoptosis cascade via caspase-8 and caspase-3 through downregulation of the caspase antagonistic proteins c-FLIP and XIAP. Importantly, a strong increase of reactive oxygen species (ROS) was observed as an immediate early effect in response to DKP-071 treatment. The use of antioxidative pre-treatment proved the decisive role of ROS, which turned out upstream of all other proapoptotic effects monitored. Thus, reactive oxygen species appear as a highly active proapoptotic pathway in CTCL, which may be promising for therapeutic intervention. This pathway can be efficiently activated by an indirubin derivative. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
- ItemOne Pot Synthesis and Characterization of Mono and Di-Substituted Azo-Containing Amides(Shibabad : Chemic Publ. Co., 2015) Khera, Rasheed Ahmad; Iqbal, Munawar; Tahir, M. Asif; Hanif, M. Asif; Langer, PeterAzo-containing amides and their derivatives were synthesized by the reaction of 4-(phenyldiazenyl)aniline with different substituted benzoyl chlorides. The characterization of these synthesized compounds were based on their IR, 1H NMR spectra and elemental analysis with excellent yields.
- Item2,4-Bis(arylethynyl)-9-chloro-5,6,7,8-tetrahydroacridines: synthesis and photophysical properties(Frankfurt, M. : Beilstein-Institut zur Förderung der Chemischen Wissenschaften, 2021) Tka, Najeh; Ayed, Mohamed Adnene Hadj; Braiek, Mourad Ben; Jabli, Mahjoub; Chaaben, Noureddine; Alimi, Kamel; Jopp, Stefan; Langer, PeterAcridine derivatives have attracted considerable interest in numerous areas owing to their attractive physical and chemical properties. Herein, starting from readily available anthranilic acid, an efficient synthesis of 2,4-bis(arylethynyl)-9-chloro-5,6,7,8-tetrahydroacridine derivatives was accomplished via a one-pot double Sonogashira cross-coupling method. The UV-visible absorption and emission properties of the synthesized molecules have been examined. Additionally, theoretical studies based on density functional theory (DFT/B3LYP/6-31G(d)) were carried out.
- ItemPalladium-catalyzed synthesis and nucleotide pyrophosphatase inhibition of benzo[4,5]furo[3,2-b]indoles(Frankfurt, Main : Beilstein-Institut zur Förderung der Chemischen Wissenschaften, 2019) Do, Hoang Huy; Ullah, Saif; Villinger, Alexander; Lecka, Joanna; Sévigny, Jean; Ehlers, Peter; Iqbal, Jamshed; Langer, PeterA two-step palladium-catalyzed procedure based on Suzuki–Miyaura cross coupling, followed by a double Buchwald–Hartwig reaction, allows for the synthesis of pharmaceutically relevant benzo[4,5]furo[3,2-b]indoles in moderate to very good yield. The synthesized compounds have been analyzed with regard to their inhibitory activity (IC50) of nucleotide pyrophosphatases h-NPP1 and h-NPP3. The activity lies in the nanomolar range. The results were rationalized based on docking studies. © 2019 Do et al.